{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:01:32Z","timestamp":1767988892356,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite abnormal clotting, circuits clot during continuous renal replacement therapy (<jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content>) in children with acute liver failure (<jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>). We report our experience. All children with <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> needing <jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content> were studied over 2 years. Patient and circuit factors associated with circuit use were evaluated. Thirty\u2010one children in liver failure (median age 7.4 years) underwent <jats:styled-content style=\"fixed-case\">CRRT,<\/jats:styled-content> of which 17 (54.8%) died. A total of 98 filtration episodes were used. The smallest access catheter was 6.5\u2009Fr, while the largest was 13.5\u2009Fr. The most common filter used was <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>7 (63%). Mean duration (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) of circuit use was 33.13(30.83) hours. Of the 98 filtration episodes, circuits blocked in 25, whereas the access catheter blocked in 25. Fifty\u2010two circuits were changed electively for a variety of reasons. Prostacyclin was the anticoagulant in 62 filtration episodes. The remaining filtration episodes had either no anticoagulation or heparin. The mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) \u201cdowntime\u201d was 5.13 (9.15) hours. We found a significant association between fresh frozen plasma (<jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>) use with circuit blockade. Neither the duration of <jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content> nor the \u201cdowntime\u201d influenced mortality. The <jats:styled-content style=\"fixed-case\">CRRT<\/jats:styled-content> circuits blocked in children despite deranged clotting in liver disease. Circuits are changed for a variety of reasons other than clotting. The use of <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content> reduces circuit life.<\/jats:p>","DOI":"10.1111\/1744-9987.12224","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:30:00Z","timestamp":1409895000000},"page":"16-22","source":"Crossref","is-referenced-by-count":27,"title":["Factors Affecting Circuit Life During Continuous Renal Replacement Therapy in Children With Liver Failure"],"prefix":"10.1111","volume":"19","author":[{"given":"Chulananda D","family":"Goonasekera","sequence":"first","affiliation":[{"name":"Paediatric Intensive Care Unit King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Wang","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E","family":"Bunchman","sequence":"additional","affiliation":[{"name":"Children's Hospital of Richmond VCU School of Medicine  Richmond CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Deep","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2011.01450.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.56.s72.9.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jarr.2001.26347"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8933"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MAT.0000104822.30759.A7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.05.028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2438-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12369"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7000"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880703001212"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6965"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319001"},{"key":"e_1_2_8_14_1","first-page":"55","article-title":"Factors affecting system clotting in continuous renal replacement therapy: results of a randomized, controlled trial","volume":"53","author":"Ramesh Prasad GV","year":"2000","journal-title":"Clin Nephrol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000055374.77132.4D"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187859"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.01.048"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg459"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5080"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc4903"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860229009087125"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000221322.98590.99"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2006.00134.x"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:10:48Z","timestamp":1696165848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,4]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/1744-9987.12224"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12224","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,4]]}}}