{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:16:12Z","timestamp":1694596572312},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients with critical limb ischemia (<jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>) suffer chronic inflammation and repeated infection, require intervention, and may have a protracted hospital stay. Therefore, early prediction is particularly important for management of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> in patients with suspected peripheral artery disease. The purpose of this study is to develop a simple score for predicting the incidence of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients with suspected peripheral artery disease. The subjects were 139 asymptomatic patients receiving maintenance <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> and with <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content> &lt;1.0. Multivariate logistic regression analysis was used to identify factors associated with development of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>. These factors were subsequently weighted and integrated into a scoring system for the prediction of onset of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>. Twenty\u2010five patients had onset of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>. Five factors selected from the multivariate model were weighted proportionally using their respective odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) for incidence of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> (history of cerebral vascular disease, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.42 [3 points]; diabetes, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.92 [2 points]; hypoesthesia, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.21 [2 points]; left ventricular ejection fraction &lt;50%, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.89 [2 points]; serum albumin &lt;3.5\u2009g\/dL, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.39 [2 points]). Three strata of risk were defined (low risk, 0 to 3 points; intermediate risk, 4 to 6 points; and high risk 7 to 11 points) with excellent prognostic accuracy for progression to <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> using the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier method. Five factors were identified that increased the risk of progression to <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients with suspected peripheral artery disease. A combination of those factors permitted establishment of three risk strata for accurate prediction of onset of <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1744-9987.12287","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T08:23:28Z","timestamp":1427271808000},"page":"378-384","source":"Crossref","is-referenced-by-count":4,"title":["Prediction of Development of Critical Limb Ischemia in Hemodialysis Patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Hisao","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Yoshikawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raisuke","family":"Iijima","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Toho University Ohashi Medical Center  Tokyo 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