{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:10:02Z","timestamp":1785798602784,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>The long\u2010term effect of cinacalcet hydrochloride treatment on parathyroid gland (PTG<\/jats:styled-content>) volume has been scarcely investigated in patients with moderate to advanced secondary hyperparathyroidism (SHPT<\/jats:styled-content>). The present study was a prospective observational study to determine the effect of cinacalcet treatment on PTG<\/jats:styled-content> volume and serum biochemical parameters in 60 patients with renal SHPT<\/jats:styled-content>, already treated with intravenous vitamin D<\/jats:styled-content> receptor activator (VDRA<\/jats:styled-content>). Measurement of biochemical parameters and PTG<\/jats:styled-content> volumes were performed periodically, which were analyzed by stratification into tertiles across the baseline parathyroid hormone (PTH<\/jats:styled-content>) level or PTG<\/jats:styled-content> volume. We also determined the factors that can estimate the changes in PTG<\/jats:styled-content> volume and the achievement of the target PTH<\/jats:styled-content> range by multivariable analyses. Two years of cinacalcet treatment significantly decreased the serum levels of PTH<\/jats:styled-content>, calcium, and phosphate, followed by the improvement of achieving the target ranges for these parameters recommended by the J<\/jats:styled-content>apanese Society for Dialysis Therapy. Cinacalcet decreased the maximal and total PTG<\/jats:styled-content> volume by about 30%, and also decreased the serum PTH<\/jats:styled-content> level independent of the baseline serum PTH<\/jats:styled-content> level and PTG<\/jats:styled-content> volume. Ten out of 60 patients showed 30% increase in maximal PTG<\/jats:styled-content> after 2 years. Multivariable analysis showed that patients with nodular PTG<\/jats:styled-content> at baseline and patients with higher serum calcium and PTH<\/jats:styled-content> levels at 1 year were likely to exceed the target range of PTH<\/jats:styled-content> at two years. In conclusion, cinacalcet treatment with intravenous VDRA<\/jats:styled-content> therapy decreased both PTG<\/jats:styled-content> volume and serum intact PTH<\/jats:styled-content> level, irrespective of the pretreatment PTG<\/jats:styled-content> status and past treatment history.<\/jats:p>","DOI":"10.1111\/1744-9987.12292","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T04:48:39Z","timestamp":1428468519000},"page":"367-377","source":"Crossref","is-referenced-by-count":20,"title":["Two Years of Cinacalcet Hydrochloride Treatment Decreased Parathyroid Gland Volume and Serum Parathyroid Hormone Level in Hemodialysis Patients With Advanced Secondary Hyperparathyroidism"],"prefix":"10.1111","volume":"19","author":[{"given":"Shunsuke","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science Kyushu University Fukuoka Japan"},{"name":"Department of Internal Medicine Fukuoka Dental College Fukuoka 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