{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T13:45:05Z","timestamp":1746452705137},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There have been few reports of carboplatin\u2010based chemotherapy for anuric infants. As we had a chance to treat a one\u2010year\u2010old anuric hepatoblastoma patient with carboplatin, we performed a pharmacokinetic analysis and examined the optimal treatment strategy. A one\u2010year\u2010old anuric boy under peritoneal dialysis was diagnosed with hepatoblastoma. Surgical resection was performed, and administration of carboplatin was scheduled postoperatively aiming at 5\u2009mg\u00b7min\/mL of the area under the curve from the time of dosing to the time of the last observation (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u2010t<\/jats:sub>). We set the initial dose at 50\u2009mg, higher than that calculated by the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>alvert formula (34\u2009mg); the time from the end of carboplatin infusion to the initiation of hemodialysis at 2\u2009h; and the hemodialysis duration at 24\u2009h. The actual <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u2010t<\/jats:sub> was 3.05\u2009mg\u00b7min\/mL because the elimination half\u2010lives before and during hemodialysis were shorter than expected. The AUC<jats:sub>0\u2010t<\/jats:sub> after the second dose (100\u2009mg) and the third dose (80\u2009mg) were 7.00 and 4.68\u2009mg\u00b7min\/mL, respectively. The Calvert formula is not suitable for hemodialysis patients because removal of platinum by hemodialysis is not taken into account. It appears that extrarenal clearance in anuric infants is different from that in adults. We obtained an optimal <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u2010t<\/jats:sub> using a dose of 80\u2009mg (200\u2009mg\/m<jats:sup>2<\/jats:sup>), setting the time from the end of carboplatin infusion to the initiation of hemodialysis at 2\u2009h, and performing 8\u2010h hemodialysis. Further accumulation of the pharmacokinetic data of carboplatin is necessary for anuric children.<\/jats:p>","DOI":"10.1111\/1744-9987.12302","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T10:17:40Z","timestamp":1430129860000},"page":"491-496","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacokinetics of Carboplatin in a One\u2010Year\u2010Old Anuric Boy Undergoing Hemodialysis and a Review of the Literature"],"prefix":"10.1111","volume":"19","author":[{"given":"Koichi","family":"Kamei","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Sako","sequence":"additional","affiliation":[{"name":"Division for Clinical Trials, Department of Development Strategy, Center for Social and Clinical Research, National Research Institute for Child Health and Development National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruaki","family":"Uno","sequence":"additional","affiliation":[{"name":"Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Kiyotani","sequence":"additional","affiliation":[{"name":"Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Mori","sequence":"additional","affiliation":[{"name":"Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division for Clinical Trials, Department of Development Strategy, Center for Social and Clinical Research, National Research Institute for Child Health and Development National Center for Child Health and Development  Tokyo 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