{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:35:43Z","timestamp":1765827343421,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with autosomal dominant polycystic kidney disease and polycystic liver disease (<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>) often have elevated serum levels of alkaline phosphatase (<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>) and gamma\u2010glutamyl transpeptidase (<jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content>). Ursodeoxycholic acid (<jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content>) is used to treat biliary tract diseases, but its effect on <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content> remains unclear. <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> was administered for 1 year at a dose of 300\u2009mg daily to seven <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content> patients with elevated <jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> levels who were selected for this treatment by experienced clinicians. Laboratory data and liver volumes were compared among three time points: 1 year before <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> treatment, at the start of <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> therapy, and 1 year after the start of therapy. Median <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> did not show a significant change between 1 year before <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> (180\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L) and the start of <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> therapy (209\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L), but it decreased significantly to 98\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L after 1 year of <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> therapy (<jats:italic>P<\/jats:italic>\u2009=\u20090.015 vs. the start of therapy). <jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content> showed a significant increase from 1 year before <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> (456\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L) to the start of <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> therapy (561\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L), and then decreased significantly after 1 year of <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> therapy (364\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L). Median liver volume did not show any significant changes among these three time points of assessment. <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> may be effective for reducing biliary enzyme levels and inhibiting the growth of liver cysts in patients with <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1744-9987.12326","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T13:18:26Z","timestamp":1445347106000},"page":"73-78","source":"Crossref","is-referenced-by-count":10,"title":["Ursodeoxycholic Acid for Treatment of Enlarged Polycystic Liver"],"prefix":"10.1111","volume":"20","author":[{"given":"Takashi","family":"Iijima","sequence":"first","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Suwabe","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Sumida","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Mise","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kawada","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Imafuku","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital  Kajigaya 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