{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:11:20Z","timestamp":1768684280098,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>End\u2010stage renal disease is associated with atherothrombosis (ATIS<\/jats:styled-content>), which, in turn, can promote peripheral arterial occlusive disease (PAOD<\/jats:styled-content>), coronary artery disease (CAD<\/jats:styled-content>), and\/or cerebrovascular disease (CVD<\/jats:styled-content>). The aim of this study was to determine whether low plantar skin perfusion pressure (SPP<\/jats:styled-content>) was related to ATIS<\/jats:styled-content> among 122 patients receiving maintenance hemodialysis (HD<\/jats:styled-content>) from M<\/jats:styled-content>arch to N<\/jats:styled-content>ovember 2013 at our outpatient facility. We routinely measured SPP<\/jats:styled-content> and used the value for analysis. In addition, we retrospectively evaluated the prevalence of ATIS<\/jats:styled-content> with patients categorized to CAD<\/jats:styled-content>, CVD<\/jats:styled-content>, or PAOD<\/jats:styled-content> groups. Of the 122 outpatients, ATIS<\/jats:styled-content> was diagnosed in about half (N<\/jats:italic>\u2009=\u200960, 49.2% vs. 62, 50.8%; average SPP<\/jats:styled-content>, 56.6 vs. 72.9\u2009mm\u2009Hg, respectively). These data show that SPP<\/jats:styled-content> was significantly lower in patients with ATIS<\/jats:styled-content> (difference, 16.3\u2009mm\u2009Hg; P<\/jats:italic>\u2009<\u20090.001) and there was a negative relationship between average SPPs and past history of ATIS<\/jats:styled-content> complications. When the patients were stratified by the presence of diabetes mellitus, this trend was stronger. Particularly, receiver operating characteristic analysis of HD<\/jats:styled-content> patients with diabetes revealed a cutoff point of 53.0\u2009mm\u2009Hg and an area under the curve value of 0.84, with a sensitivity of 77.0% and specificity of 91.3%. Therefore, we concluded that SPP<\/jats:styled-content> enables the evaluation of not only local PAOD<\/jats:styled-content>, but also systemic ATIS<\/jats:styled-content>. Moreover, we found that a cutoff point of 53.0\u2009mm\u2009Hg was useful for detection of ATIS<\/jats:styled-content> in HD<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/1744-9987.12327","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T13:18:30Z","timestamp":1445347110000},"page":"40-45","source":"Crossref","is-referenced-by-count":8,"title":["Skin Perfusion Pressure and the Prevalence of Atherothrombosis in Hemodialysis Patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Maki","family":"Hiratsuka","sequence":"first","affiliation":[{"name":"Department of Nephrology Kariya Toyota General Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kariya Toyota General Hospital Aichi 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