{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:16Z","timestamp":1789609216279,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Generalized pustular psoriasis (<jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>) is a type of neutrophilic dermatosis that is sometimes resistant to medications. In patients with neutrophilic skin diseases, granulocyte and monocyte adsorption apheresis (<jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content>) has been demonstrated to selectively and efficiently eliminate myeloid\u2010lineage leukocytes from the peripheral blood. We evaluated the efficacy and safety of repeated <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> therapy in three refractory <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> patients. Three <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> patients refractory to previous therapies received weekly <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> with five sessions per course, which was repeated when the symptoms reappeared. The efficacy was assessed by the disease severity scores 2 weeks after each course of <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> severity scores of all three patients were reduced in all courses (<jats:italic>N<\/jats:italic>\u2009=\u20099); they were reduced by more than 3 points in six courses and by 2 points in three courses. After the first <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> course, the <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> severity scores were reduced by more than 3 points in all three patients. On average, the <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> severity scores were reduced by 4.67 and 3.67 points after the first course and repeated courses, respectively. The severity of edema and pustules were particularly improved in all patients and no adverse effects were observed. <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> showed efficacy for the treatment of refractory <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> patients as a non\u2010pharmacologic intervention without any associated adverse effects, and was particularly effective in the first course, but also effective in the subsequent courses.<\/jats:p>","DOI":"10.1111\/1744-9987.12342","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T15:07:41Z","timestamp":1442675261000},"page":"336-341","source":"Crossref","is-referenced-by-count":21,"title":["Granulocyte and Monocyte Adsorption Apheresis for Generalized Pustular Psoriasis: Therapeutic Outcomes in Three Refractory Patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Tomomi","family":"Fujisawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Disaster Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Emergency and Disaster Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Disaster Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Seishima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu 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