{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:18:21Z","timestamp":1789215501708,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diastolic dysfunction (DD) commonly causes heart failure with preserved ejection fraction (EF). Here, we examine associations between DD severity and atherosclerosis\/vascular calcification in hemodialysis patients. Echocardiography was performed on 101 patients undergoing hemodialysis therapy. Twelve patients (EF &lt; 50% or chronic atrial fibrillation) were excluded; DD of the remaining 89 patients was classified into four grades. We then investigated the relationship between their DD grades and the cardio\u2010ankle vascular index (CAVI), ankle\u2010brachial pressure index (ABI), toe\u2010brachial pressure index (TBI), and aortic calcification area index (ACAI). Seventy\u2010seven patients (86.5%) with EF \u2265 50% had DD. Associations with advanced age and comorbid diabetes mellitus and cardiovascular disease were observed. The CAVI, TBI, and ACAI, but not ABI, increased proportionally with DD grades. Thus, many hemodialysis patients developed DD, with systolic function maintained. Strong associations between DD grades and progression of both atherosclerosis and vascular calcification could be inferred.<\/jats:p>","DOI":"10.1111\/1744-9987.12354","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T07:01:30Z","timestamp":1452754890000},"page":"135-141","source":"Crossref","is-referenced-by-count":10,"title":["Relationship Between Diastolic Dysfunction and Atherosclerosis and Vascular Calcification in Hemodialysis Patients: Diagnostic Potential of the Cardio\u2010Ankle Vascular Index"],"prefix":"10.1111","volume":"20","author":[{"given":"Kohei","family":"Unagami","sequence":"first","affiliation":[{"name":"Department of Medicine, Kidney Center Tokyo Women's Medical University  Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kidney Center Tokyo Women's Medical University  Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichiro","family":"Tago","sequence":"additional","affiliation":[{"name":"Matsushita Nephrology Clinic  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumichi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Matsushita Nephrology Clinic  Yamanashi 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