{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:42Z","timestamp":1759336302618},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with severe hepatitis C virus (HCV) recurrence after liver transplantation (LT) present an ominous prognosis, rarely achieving sustained virological response (SVR). Dialysis procedures may transiently decrease the HCV viral load, but the effect of albumin dialysis is currently unknown. Here, we evaluated the impact of albumin dialysis using the Molecular Adsorbent Recirculating System (MARS) used as a co\u2010adjuvant antiviral treatment for severe HCV recurrence after LT. Thirteen patients (11 males, median age 48\u2009years) with fibrosing cholestatic hepatitis or METAVIR fibrosis score \u2265 F3 with severe portal hypertension underwent three consecutive MARS sessions. Antiviral therapy was initiated in 11 patients within 24\u2009h after the MARS sessions. A contemporary cohort of seven patients who did not follow the MARS protocol is shown for comparison. MARS treatment resulted in consistent decreases of viral load from 7.59\u2009log<jats:sub>10<\/jats:sub> IU\/mL [6.15\u20138.90] to 6.79\u2009log<jats:sub>10<\/jats:sub> IU\/mL [5.18\u20137.84] (<jats:italic>P\u2009=<\/jats:italic>\u20090.003) as well as in decreases of serum bilirubin, gamma\u2010glutamyl transpeptidase, alanine aminotransferase and aspartate aminotransferase (all <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05). The overall rate of SVR was 0% in the Control group and 54.6% in patients initiating antiviral therapy within 24\u2009h after MARS. Survival at 1 and 3 years was, respectively, 93% and 70% in patients undergoing MARS, compared with 29% and 14% in the Control group (<jats:italic>P\u2009=<\/jats:italic>\u20090.001). No major adverse events related to MARS treatment were observed. In conclusion, the use of MARS may facilitate the achievement of SVR and improve the prognosis of patients with severe HCV\u2010recurrence after LT by reducing viral load and improving liver function prior to antiviral therapy.<\/jats:p>","DOI":"10.1111\/1744-9987.12381","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T06:04:12Z","timestamp":1456812252000},"page":"189-196","source":"Crossref","is-referenced-by-count":1,"title":["Liver Support With Albumin Dialysis Reduces Hepatitis C Virus Viremia and Facilitates Antiviral Treatment of Severe Hepatitis C Virus Recurrence After Liver Transplantation"],"prefix":"10.1111","volume":"20","author":[{"given":"Luis","family":"Ib\u00e1\u00f1ez\u2010Samaniego","sequence":"first","affiliation":[{"name":"Unidad de Hepatolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Vega","family":"Catalina","sequence":"additional","affiliation":[{"name":"Unidad de Hepatolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"},{"name":"CIBERehd Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Hepatolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"},{"name":"CIBERehd Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oreste","family":"Lo Iacono","sequence":"additional","affiliation":[{"name":"Servicio de Gastroenterolog\u00eda Hospital del Tajo  Aranjuez Madrid 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Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"},{"name":"CIBERehd Instituto de Salud Carlos III  Madrid Spain"},{"name":"Facultad de Medicina Universidad Complutense  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Vaquero","sequence":"additional","affiliation":[{"name":"Unidad de Hepatolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"},{"name":"CIBERehd Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Unidad de Hepatolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"},{"name":"CIBERehd Instituto de Salud Carlos III  Madrid 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