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TA can be used during the entire course of the pregnancy with the following purposes: (i) to treat several maternal acute and chronic conditions; (ii) to treat fetal conditions; (iii) to avoid administration of drugs potentially harmful to the fetus; and (iv) to reach a more advanced gestational age in order to prevent fetal prematurity. We report three successfully treated patients throughout pregnancy, for differential indications: thrombotic thrombocytopenic purpura, red blood cells alloimmunization and ulcerative colitis. Multiple courses of TA have been performed without any complications for the mother and the fetus. A review and a discussion on the particular TA implications related to maternal\u2010fetal medicine have been reported. When approaching TA in pregnancy, clinicians have to consider the severity of disease, the strength of the indications, and the gestational age. Each case must be evaluated individually on the basis of existing evidence since, despite the increasing use, specific guidelines for apheresis in pregnancy are still lacking.<\/jats:p>","DOI":"10.1111\/1744-9987.12422","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T09:21:51Z","timestamp":1468488111000},"page":"677-685","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic Apheresis in Pregnancy: Three Differential Indications With Positive Maternal and Fetal Outcome"],"prefix":"10.1111","volume":"20","author":[{"given":"Giuseppina","family":"Perrone","sequence":"first","affiliation":[{"name":"Department of Obstetrical and Gynecological Sciences and Urological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrical and Gynecological Sciences and Urological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Marcoccia","sequence":"additional","affiliation":[{"name":"Department of Obstetrical and Gynecological Sciences and Urological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Zannini","sequence":"additional","affiliation":[{"name":"Department of Obstetrical and Gynecological Sciences and Urological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Candelieri","sequence":"additional","affiliation":[{"name":"Department of Obstetrical and Gynecological Sciences and Urological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gozzer","sequence":"additional","affiliation":[{"name":"Immunohematology and Transfusion Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Stefanutti","sequence":"additional","affiliation":[{"name":"Extracorporeal Therapeutic Techniques Unit, Immunohematology and Transfusion Medicine, Lipid Clinic and Atherosclerosis Prevention Centre, Department of Molecular Medicine \u2018Umberto I\u2019 Hospital, \u2018Sapienza\u2019 University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21276"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21334"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.034793"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12760"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.10.291"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2012.10.020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0579-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2730"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661167"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00199-4"},{"key":"e_1_2_7_12_1","first-page":"119","article-title":"Thrombotic microangiopathy in pregnancy and the postpartum period","volume":"24","author":"Weiner CP","year":"1987","journal-title":"Semin Hematol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07515.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250604"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0236"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2014.08.001"},{"key":"e_1_2_7_17_1","article-title":"Twice\u2010daily therapeutical plasma exchange\u2010based salvage therapy in severe autoimmune thrombotic thrombocytopenic purpura: the French TMA Reference Center experience","author":"Soucemarianadin M","year":"2015","journal-title":"Eur J Haematol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2010.05.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-553131"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408914"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200608000-00044"},{"key":"e_1_2_7_23_1","first-page":"915","article-title":"Fetal erythrocytes in the maternal circulation of pregnant women","volume":"23","author":"Clayton EM","year":"1964","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.02.007"},{"key":"e_1_2_7_25_1","first-page":"101","article-title":"Ante\u2010partum administration of preventive treatment of Rh\u2010D immunization in rhesus\u2010negative women. 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