{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:23:53Z","timestamp":1761513833789},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antibody\u2010mediated rejection (AMR) is a major cause of kidney graft failure. We aimed to analyze treatment and outcome of AMR in a national cohort of 75 biopsy\u2010proven acute (43 patients, 57%) or chronic active (32 patients, 43%) AMR episodes between 2000 and 2015. The mean patients' age was 46\u2009\u00b1\u200916\u2009years, the majority was treated with plasma exchange, 4% received immunoadsorption and 7% received both. The majority received pulse methylprednisolone and low\u2010dose CMV hyperimmune globulin, 20% received bortezomib and 13% rituximab. Concomitant infection was treated in 40% of patients. The immediate treatment outcome was successful in 91%, the 1\u2010 and 3\u2010year graft survival rates were 71% and 57%, while 3\u2010year patient survival was 97%. Chronic active AMR was associated with worse graft survival than acute AMR (log rank <jats:italic>P\u2009=<\/jats:italic>\u20090.06). To conclude, intensive treatment with apheresis and additional immunosuppression was effective in reversing AMR, but long\u2010term graft survival remains markedly decreased, especially in chronic active AMR.<\/jats:p>","DOI":"10.1111\/1744-9987.12430","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T01:28:37Z","timestamp":1466126917000},"page":"240-245","source":"Crossref","is-referenced-by-count":14,"title":["Treatment of Antibody\u2010Mediated Rejection After Kidney Transplantation \u2013 10 Years\u2019 Experience With Apheresis at a Single Center"],"prefix":"10.1111","volume":"20","author":[{"given":"Jakob","family":"Gubensek","sequence":"first","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadranka","family":"Buturovic\u2010Ponikvar","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aljosa","family":"Kandus","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miha","family":"Arnol","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana 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