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PD solution was supplemented with methylglyoxal, a major glucose\u2010derived RCO, to quench intraperitoneal pyridoxamine. Oral pyridoxamine achieved comparable blood and dialysate pyridoxamine concentrations, suppressed pentosidine accumulation in the blood but not in the mesenterium or dialysate, and reduced the increases in small solute transport and mesenteric vessel densities, with no effects on submesothelial matrix layer thickening or serum creatinine. Thus, reducing circulating RCOs by giving oral pyridoxamine with PD provides limited peritoneal protection. However, orally given pyridoxamine efficiently reaches the peritoneal cavity and would eliminate intraperitoneal RCOs. Oral pyridoxamine is more clinically favorable and may be as protective as intraperitoneal administration.<\/jats:p>","DOI":"10.1111\/1744-9987.12446","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T06:57:02Z","timestamp":1473749822000},"page":"645-654","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Scavenging Circulating Reactive Carbonyls by Oral Pyridoxamine in Uremic Rats on Peritoneal Dialysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Yoshitaka","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Nephrology, Endocrinology and Metabolism Tokai University School of Medicine  Isehara Japan"},{"name":"Unit of Translational Medicine, Department of Endocrinology and Metabolism Nagasaki University Graduate School of Biomedical Sciences  Nagasaki 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