{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:43Z","timestamp":1789609123912,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess the clinical benefit of combined treatment of below\u2010knee endovascular therapy (BK\u2010EVT) plus low\u2010density lipoprotein apheresis (LDLA) compared with BK\u2010EVT monotherapy, we retrospectively evaluated the clinical outcome of hemodialysis (HD) patients with critical limb ischemia (CLI) due to isolated BK arterial lesions who underwent BK\u2010EVT or BK\u2010EVT plus short\u2010term LDLA. Between October 2011 and September 2014, 62 HD patients underwent isolated BK\u2010EVT monotherapy (BK\u2010EVT group), and 25 HD patients underwent BK\u2010EVT plus LDLA (BK\u2010EVT\u2009+\u2009LDLA group). LDLA was started within 1\u2009week after BK\u2010EVT and performed four times in total within next 2\u2009weeks. Major adverse limb events (MALE) including major amputation and re\u2010intervention, and all\u2010cause mortality were examined by Kaplan\u2013Meier method and the log\u2010rank test. Baseline characteristics were not different other than low ABI and low dorsal SPP in BK\u2010EVT\u2009+\u2009LDLA group. Cumulative MALE\u2010free rate was significantly improved in BK\u2010EVT\u2009+\u2009LDLA group over the BK\u2010EVT group (72.0% and 45.1% respectively at 30\u2009months after treatment, <jats:italic>P\u2009=<\/jats:italic>\u20090.04). All\u2010cause mortality did not differ between the two groups. Major causes of death were heart failure and sepsis in both groups. Short\u2010term LDLA hybrid treatment immediately after BK\u2010EVT might improve the outcome of ischemic limbs after re\u2010vascularization therapy.<\/jats:p>","DOI":"10.1111\/1744-9987.12450","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T09:24:05Z","timestamp":1468488245000},"page":"661-667","source":"Crossref","is-referenced-by-count":17,"title":["Beneficial Effect of Endovascular Therapy and Low\u2010Density Lipoprotein Apheresis Combined Treatment in Hemodialysis Patients With Critical Limb Ischemia due to Below\u2010Knee Arterial Lesions"],"prefix":"10.1111","volume":"20","author":[{"given":"Takayasu","family":"Ohtake","sequence":"first","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Mochida","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Matsumi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Catheterization Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Tobita","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Catheterization Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Ishioka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Maesato","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Catheterization Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine, Kidney and Dialysis Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2015.03.034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25676"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.25056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.09.070"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.07.017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.042"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.10.026"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20033"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2006.00332.x"},{"key":"e_1_2_7_11_1","first-page":"287","article-title":"Effect of low\u2010density lipoprotein apheresis on patients with peripheral arterial disease. 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