{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:57:00Z","timestamp":1777517820199,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Double\u2010filtration plasmapheresis is an effective and safe treatment for pemphigus. We retrospectively evaluated the decrease in autoantibody titer and pemphigus disease area index following double\u2010filtration plasmapheresis in five patients with moderate to severe pemphigus, who were physically and\/or serologically unresponsive to 1.0\u00a0mg\/kg per day of prednisolone and other supportive drugs and ointments. The percentage reduction in autoantibodies 85.6\u00a0\u00b1\u00a014.4% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00014), and that in pemphigus disease area index was 75.4\u00a0\u00b1\u00a024.3% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0023). No side\u2010effects were observed. All patients exhibited clinical improvement after undergoing double\u2010filtration plasmapheresis, and the prednisolone dose was reduced by 41\u00a0\u00b1\u00a08.9\u00a0mg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005) approximately 3\u00a0months after double\u2010filtration plasmapheresis. To our knowledge, this is the first report evaluating the efficacy of double\u2010filtration plasmapheresis with pemphigus disease area index, and it demonstrated that double\u2010filtration plasmapheresis is a safe \u201csubtracting\u201d treatment for patients with drug\u2010resistant pemphigus.<\/jats:p>","DOI":"10.1111\/1744-9987.12557","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T10:45:13Z","timestamp":1498733113000},"page":"243-247","source":"Crossref","is-referenced-by-count":14,"title":["Evaluating the Efficacy of Double\u2010Filtration Plasmapheresis in Treating Five Patients With Drug\u2010Resistant Pemphigus"],"prefix":"10.1111","volume":"21","author":[{"given":"Takaaki","family":"Higashihara","sequence":"first","affiliation":[{"name":"Divisions of Nephrology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Kawase","sequence":"additional","affiliation":[{"name":"Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maasa","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Hara","sequence":"additional","affiliation":[{"name":"Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Uni","sequence":"additional","affiliation":[{"name":"Divisions of Nephrology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimiko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Divisions of Nephrology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Etoh","sequence":"additional","affiliation":[{"name":"Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Takano","sequence":"additional","affiliation":[{"name":"Divisions of Nephrology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650430127024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890260105016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb15095.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70111-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb01630.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70004-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.1997.tb00037.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.01.008"},{"key":"e_1_2_7_11_1","first-page":"91","article-title":"Clinical evaluation method for the apheresis in the treatment of dermatological diseases","volume":"33","author":"Yamada H","year":"2014","journal-title":"Nihon Apheresis Gakkai Zasshi"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_13_1","first-page":"1443","article-title":"The therapeutic guidelines for pemphigus","volume":"120","author":"Amagai M","year":"2010","journal-title":"Nihon Hifuka Gakkai Zasshi"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01706318"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.132.6.1279"},{"key":"e_1_2_7_16_1","first-page":"32","article-title":"Specific suppression of antibody rebound after extracorporeal immunoadsorption. 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