{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:47:50Z","timestamp":1785340070051,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plant phenols may accumulate in end\u2010stage kidney disease. The effect of hemodialysis on their plasma concentration remains poorly determined. Contingent on concentration, health\u2010promoting or noxious effects occur; therefore, we assessed plasma concentration in hemodialyzed patients. In total, 21 maintenance hemodialyzed patients with diuresis &lt; 500 mL per day (with oliguria), nine hemodialyzed patients with diuresis \u2265 500 mL per day (without oliguria) and 31 healthy volunteers were included. Nine phenolic acids were identified with high\u2010performance liquid chromatography and total polyphenol concentration was determined with the Folin\u2013Ciocalteu method in pre\u2010 or post\u2010hemodialysis plasma and pre\u2010 or intra\u2010hemodialysis dialysate. The concentration of total polyphenols was 27% higher in pre\u2010hemodialysis plasma than in that of controls (0.95 \u00b1 0.18 mmol\/L [<jats:italic>P<\/jats:italic>&lt; 0.0001]). The concentration of total polyphenols was higher in patients with oliguria (1.01 \u00b1 0.17) than in those without (0.84 \u00b1 0.13 mmol\/L), despite the former having more intense hemodialysis (Kt\/V 1.29 \u00b1 0.31 and 0.77 \u00b1 0.25, respectively). Pre\u2010hemodialysis phenolic acid concentration in patients undergoing dialysis exceeded reference values by 3 to 34 times (3\u2010hydroxyphenylacetic acid and vanillic acid, respectively), from 0.69 (dihydrocaffeic acid) to 169.3 \u03bcmol\/L (hippuric acid). The concentration of six phenolic acids (3\u2010hydroxyhippuric, caffeic, dihydrocaffeic, hippuric, homovanillic, and vanillic acid) was 1.1 (homovanillic) to 11.3 (3\u2010hydroxyhippuric) times higher in patients with oliguria than in those without. 4\u2010hydroxyhippuric acid occurred more in the plasma of patients with oliguria than in those without oliguria. A single hemodialysis session decreased total polyphenol concentration by 16% and phenolic acids from 30% (caffeic) to 58% (vanillic and 3\u2010hydroxyphenylacetic acid) and these compounds appeared in the dialysate. The percentage decrease (\u0394%) of creatinine concentration correlated with the \u0394% of total polyphenols and five phenolic acids (3\u2010hydroxyphenylacetic, dihydrocaffeic, hippuric, homovanillic, and vanillic acid). Urea \u0394% and Kt\/V correlated only with the \u0394% of homovanilic acid. The results demonstrate that phenols accumulate variably in hemodialyzed patients and are differently eliminated during hemodialysis. Residual renal function ensures a lower concentration of plasma phenols.<\/jats:p>","DOI":"10.1111\/1744-9987.12586","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T06:46:38Z","timestamp":1507704398000},"page":"572-585","source":"Crossref","is-referenced-by-count":12,"title":["Hemodialysis Decreases the Concentration of Accumulated Plant Phenols in the Plasma of Patients on Maintenance Dialysis: Influence of Residual Renal Function"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-0682","authenticated-orcid":false,"given":"Piotr Jan","family":"Nowak","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hypertension, and Kidney Transplantation Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslaw","family":"Wilk","sequence":"additional","affiliation":[{"name":"Dialysis Center, Central Veterans Hospital Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Prymont\u2010Przyminska","sequence":"additional","affiliation":[{"name":"Department of General Physiology Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zwolinska","sequence":"additional","affiliation":[{"name":"Cell\u2010to\u2010Cell Communication Department Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Sarniak","sequence":"additional","affiliation":[{"name":"Department of General Physiology Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wlodarczyk","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"de Graft\u2010Johnson","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute of North Florida Tallahassee FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Mamelka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics and Clinical Biochemistry Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zasowska\u2010Nowak","sequence":"additional","affiliation":[{"name":"Palliative Medicine Laboratory Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Bartnicki","sequence":"additional","affiliation":[{"name":"Dialysis Center, Central Veterans Hospital Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Medical 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