{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:02:04Z","timestamp":1783353724832,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PB\u2010PG\u20100110\u20102170"],"award-info":[{"award-number":["PB\u2010PG\u20100110\u20102170"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009891","name":"International Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemodialysis patients (HD) commonly report fatigue. Muscle wasting (sarcopenia) and extracellular water (ECW) excess have been reported to be associated with fatigue in other conditions. We wished to determine whether muscle loss and ECW excess were associated with fatigue in HD patients. Patients completed the Multidimensional Fatigue Inventory (MFI), Beck Depression Inventory\u2010II (BDI\u2010II), Patient Health Questionnaires (PHQ\u20109) and recorded their post\u2010dialysis recovery time. Sessional dialysis data were recorded along with pre\u2010 and post\u2010dialysis multi\u2010frequency bioimpedance assessments (MFBIA). One hundred and ten patients, median age 64 (52\u201379) years, 67% male, 35% diabetic completed questionnaires and had pre\u2010 and post\u2010HD MFBIAs. Median total MFI score was 60 (48\u201372), with the physical domain having the highest score. Modal (30.8%) recovery time post\u2010dialysis was 1\u20134\u2009h. Of the participants, 35% and 34% had increased BDI\u2010II and PHQ\u20109 scores, respectively. Total MFI score was associated with increased BDI\u2010II (&gt;16) (standardized (Std) \u03b2 0.54, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), PHQ\u20109 (&gt;10) scores (Std \u03b2 0.49, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, past history of depression (Std \u03b2 0.28, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), post\u2010HD ECW\/total body water ratio (Std \u03b2 0.25, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), recovery time\u2009&gt;\u20098\u2009h (Std \u03b2 0.26, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), post dialysis mean arterial pressure (MAP) (Std \u03b2 \u22120.19, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), and muscle wasting (Std \u03b2 \u22120.15, <jats:italic>P<\/jats:italic>\u2009=\u20090.05). Self\u2010reported fatigue in HD patients is associated with self\u2010reported depression, but also dialysis\u2010related factors including increased ECW post HD, low MAP, and longer recovery times. Patients with reduced muscle mass were less likely to report fatigue, possibly accepting physical limitations. As such, interventions to reduce fluid overload and improve dialysis experience may help improve fatigue.<\/jats:p>","DOI":"10.1111\/1744-9987.12648","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T14:19:14Z","timestamp":1515593954000},"page":"152-159","source":"Crossref","is-referenced-by-count":19,"title":["Extracellular Water Excess and Increased Self\u2010Reported Fatigue in Chronic Hemodialysis Patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Kamonwan","family":"Tangvoraphonkchai","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Mahasarakham University Hospital  Mahasarakham Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4467-6833","authenticated-orcid":false,"given":"Andrew","family":"Davenport","sequence":"additional","affiliation":[{"name":"UCL Centre for Nephrology Royal Free Hospital, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.86"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430827"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03710415"},{"key":"e_1_2_7_5_1","unstructured":"SONG (Standardised Outcomes in Nephrology). 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