{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:19:21Z","timestamp":1782843561025,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T00:00:00Z","timestamp":1526774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical Co. 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Another limitation is the existence of multiple readout methods of the i\u2010PTH assay. The w\u2010PTH assay is theoretically ideal because it exclusively detects full\u2010length PTH (1\u201084). However, clinical data proving the advantages of w\u2010PTH measurement are not sufficient. For uremic patients, Kidney Disease Improving Global Outcomes suggest that PTH levels should be maintained within approximately two to nine times the upper normal limit of the i\u2010PTH assays. The most critical issue in the evaluation of PTH levels is the lack of definitive PTH assay method. Evidence\u2010based recommendations on clinical management goals of PTH are warranted.<\/jats:p>","DOI":"10.1111\/1744-9987.12690","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T02:10:00Z","timestamp":1526868600000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Critical Governance Issue of Parathyroid Hormone Assays and its Selection in the Management of Chronic Kidney Disease Mineral and Bone Disorders"],"prefix":"10.1111","volume":"22","author":[{"given":"Takatoshi","family":"Kakuta","sequence":"first","affiliation":[{"name":"Division of Nephrology, Endocrinology and Metabolism, Department of Medicine Tokai University Hachioji Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ishida","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology and Metabolism, Department of 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