{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:58:58Z","timestamp":1774418338525,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High concentrations of lactate are considered to contribute to impairment of the peritoneal membrane. We investigated the longer\u2010period effects of bicarbonate\/lactate\u2010buffered neutral peritoneal dialysis fluid (PDF) in patients undergoing PD for about 2\u2009years. Patients undergoing PD were changed from a lactate\u2010buffered neutral PDF to a bicarbonate\/lactate\u2010buffered neutral PDF. We then investigated the patients\u2019 clinical outcomes and peritoneal membrane functions as well as the surrogate markers in the drained dialysate. Fourteen patients undergoing PD were enrolled. Peritonitis was observed in one patient. No other adverse events were observed. Peritoneal function did not change as the ultrafiltration volume decreased. Fibrin degradation products and vascular endothelial growth factor in the drained dialysate decreased while the interleukin level increased. These results suggest that bicarbonate\/lactate\u2010buffered neutral PDF may have beneficial effects in terms of peritoneal preservation and can be safely used in patients undergoing PD.<\/jats:p>","DOI":"10.1111\/1744-9987.12709","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T02:46:27Z","timestamp":1531795587000},"page":"641-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Longer\u2010Period Effects of Bicarbonate\/Lactate\u2010Buffered Neutral Peritoneal Dialysis Fluid in Patients Undergoing Peritoneal Dialysis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-9769","authenticated-orcid":false,"given":"Taro","family":"Hoshino","sequence":"first","affiliation":[{"name":"Division of Nephrology, First Department of Integrated Medicine Saitama Medical Center Jichi Medical University  Saitama 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