{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:32:50Z","timestamp":1740137570282,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Direct hemoperfusion with polymyxin B\u2010immobilized fiber (PMX\u2010DHP) has been widely used for severe sepsis and septic shock. However, data are limited regarding the clinical experience and efficacy of PMX\u2010DHP for septic shock resulting from urinary tract infection (UTI). At our institution, 15 patients with septic shock resulting from a UTI received PMX\u2010DHP from January 2013 to July 2017. The cause of the urosepsis was mainly obstructive pyelonephritis secondary to ureterolithiasis or neurogenic bladder. Average Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were 25.9 \u00b1 4.3 and 10.5 \u00b1 2.2, respectively. If patients were still hypotensive after initial resuscitation, we began PMX\u2010DHP. Mean arterial pressure increased significantly from 58.3 \u00b1 9.6 mm Hg to 93.6 \u00b1 14.8 mm Hg just after PMX\u2010DHP and to 94.7 \u00b1 16.9 mm Hg (<jats:italic>P<\/jats:italic> &lt; 0.0001) 24 h after the treatment. Catecholamine index decreased significantly from 20.7 \u00b1 11.3 to 9.3 \u00b1 13.5 (<jats:italic>P<\/jats:italic> = 0.0001) 24 h after the treatment. Of 15 patients, 14 (93.3%) had survived 28 days after admission. Our results suggest a possible role for PMX\u2010DHP in the rapid stabilization of hemodynamics in patients with septic shock with an underlying UTI. These patients may be good candidates for PMX\u2010DHP.<\/jats:p>","DOI":"10.1111\/1744-9987.12746","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T06:54:36Z","timestamp":1536821676000},"page":"80-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Effects of Polymyxin B Hemoperfusion in Patients With Septic Shock Caused by Urinary Tract Infection"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-5657","authenticated-orcid":false,"given":"Yasushi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Iwate Prefectural Advanced Critical Care and Emergency Center Iwate Medical University  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kojika","sequence":"additional","affiliation":[{"name":"Iwate Prefectural Advanced Critical Care and Emergency Center Iwate Medical 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