{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:58:19Z","timestamp":1791849499104,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paricalcitol and calcitriol are widely used for the treatment of secondary hyperparathyroidism in dialysis patients. We conducted a systematic review and meta\u2010analysis to compare the efficacy and safety of paricalcitol and calcitriol for secondary hyperparathyroidism in dialysis patients. PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCT) assessing the efficacy of paricalcitol and calcitriol for secondary hyperparathyroidism in dialysis patients are included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. Meta\u2010analysis was carried out using the random\u2010effect model. Six randomized controlled trials are included in the meta\u2010analysis. Overall, compared with calcitriol treatment for secondary hyperparathyroidism in dialysis patients, paricalcitol treatment has comparable \u226550% reduction of parathyroid hormone (risk ratio [RR]\u2009=\u20091.33; 95% CI\u2009=\u20090.93\u20131.91; <jats:italic>P<\/jats:italic>\u2009=\u20090.12), calcium concentration (standard mean difference [Std. MD]\u2009=\u2009\u22120.21; 95% CI\u2009=\u2009\u22120.94 to 0.52; <jats:italic>P<\/jats:italic>\u2009=\u20090.58), phosphate concentration (Std. MD\u2009=\u2009\u22120.17; 95% CI\u2009=\u2009\u22120.58 to 0.24; <jats:italic>P<\/jats:italic>\u2009=\u20090.42), calcium phosphate (Std. MD\u2009=\u2009\u22120.08; 95% CI\u2009=\u2009\u22120.49\u20130.34; <jats:italic>P<\/jats:italic>\u2009=\u20090.71), alkaline phosphatase (Std. MD\u2009=\u2009\u22120.21; 95% CI\u2009=\u2009\u22120.73\u20130.31; <jats:italic>P<\/jats:italic>\u2009=\u20090.43), hypercalcemia (RR\u2009=\u20091.43; 95% CI\u2009=\u20090.51 to 3.98; <jats:italic>P<\/jats:italic>\u2009=\u20090.49), adverse events (RR\u2009=\u20090.79; 95% CI\u2009= 0.42\u20131.49; <jats:italic>P<\/jats:italic>\u2009=\u20090.47), and serious adverse events (RR =\u20090.78; 95% CI\u2009=\u20090.47\u20131.30; <jats:italic>P<\/jats:italic>\u2009=\u20090.33). Paricalcitol and calcitriol result in similar \u226550% reduction of parathyroid hormone, calcium concentration, phosphate concentration, calcium phosphate, alkaline phosphatase, hypercalcemia, adverse events, and serious adverse events for secondary hyperparathyroidism in dialysis patients.<\/jats:p>","DOI":"10.1111\/1744-9987.12760","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T02:53:56Z","timestamp":1539744836000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of Paricalcitol and Calcitriol in Dialysis Patients With Secondary Hyperparathyroidism: A Meta\u2010Analysis of Randomized Controlled Studies"],"prefix":"10.1111","volume":"23","author":[{"given":"Tong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Ju","sequence":"additional","affiliation":[{"name":"Nephrology Department Fenghua People's Hospital  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojun","family":"Chen","sequence":"additional","affiliation":[{"name":"Nephrology Department Fenghua People's Hospital  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-4738","authenticated-orcid":false,"given":"Wen","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12434"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S128252"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161527"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200201050-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14103869"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10423"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767140-00003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2009.00066.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0844-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10661013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12029"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_6_17_1","unstructured":"HigginsJPT GS. 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