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In dialysis patients with failed renal function, physiological mineral balance control by parathyroid hormone through the kidney fails and hyperparathyroidism progresses. In this process, many significant genetic findings have been established. Abnormalities of Ca\u2010sensing receptor and vitamin D receptor are associated with the pathogenesis of SHPT, and fibroblast growth factor 23 has also been shown to be involved in the pathogenesis. Vitamin D receptor activators (VDRAs) are widely used for treatment of SHPT. However, VDRAs have calcemic and phosphatemic effects that limit their use to a subset of patients, and calcimimetics have been developed as alternative drugs for SHPT. Hyperphosphatemia also affects progression of SHPT, and control of hyperphosphatemia is, therefore, thought to be fundamental for control of SHPT. Currently, a combination of a VDRA and a calcimimetic is recognized as the optimal strategy for SHPT, and for other outcomes such as reduced cardiovascular disease and improved survival. The latest findings on the pathogenesis and treatment of SHPT are summarized in this review.<\/jats:p>","DOI":"10.1111\/1744-9987.12772","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T21:14:39Z","timestamp":1541711679000},"page":"309-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-8414","authenticated-orcid":false,"given":"Masahide","family":"Mizobuchi","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-5575","authenticated-orcid":false,"given":"Hiroaki","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of 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