{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:13:27Z","timestamp":1770833607307,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C\u2010reactive protein (CRP) is well known as a general marker of inflammation. It furthermore represents a reliable risk factor for cardiac events and mediates tissue damage in acute myocardial infarction (AMI). It has been demonstrated that selective CRP depletion by extracorporeal apheresis in a porcine AMI model had beneficial effects on the infarcted area and the cardiac output. We therefore developed a novel adsorber for CRP apheresis from human plasma (PentraSorb CRP). It is intended for use in the clinic as therapy for patients suffering from AMI or other acute inflammatory diseases with elevated CRP plasma levels. The PentraSorb resin specifically bound CRP from human blood plasma and almost no other proteins as determined via Sodium dodecyl sulfate polyacrylamide gel electropheresis (SDS\u2010PAGE). The resin further efficiently and selectively depleted CRP from plasma with low as well as high CRP concentrations (10\u2013100\u2009mg\/L) at different flow rates, ranging from 17 to 40\u2009mL\/min. The resin was regenerable for up to 200 times without losing its CRP binding capacity or affecting biocompatibility. The depletion of CRP from plasma was comparable between the utilized small\u2010scale column (0.5\u2009mL resin) and the PentraSorb CRP adsorber (20\u2009mL resin volume). The established features can therefore be applied to the clinical setting. In summary, PentraSorb CRP provides a novel, specific, and efficient CRP\u2010binding resin that could be used in apheresis therapy for patients suffering from inflammatory diseases such as AMI, stroke, acute pancreatitis, and Crohn's disease.<\/jats:p>","DOI":"10.1111\/1744-9987.12796","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T05:09:27Z","timestamp":1548824967000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["PentraSorb C\u2010Reactive Protein: Characterization of the Selective C\u2010Reactive Protein Adsorber Resin"],"prefix":"10.1111","volume":"23","author":[{"given":"Stephan","family":"Mattecka","sequence":"first","affiliation":[{"name":"Pentracor GmbH  Hennigsdorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Brunner","sequence":"additional","affiliation":[{"name":"iAdsorb GmbH  Berlin 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