{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:15:54Z","timestamp":1776258954861,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to determine the prevalence of oral <jats:italic>Candida<\/jats:italic> spp. in HD patients and to investigate its relation with systemic inflammation and atherosclerosis. Microbiological samples were taken from buccal mucosa, palate, and dental prosthesis with a cotton swab. High\u2010sensitivity CRP (hsCRP) and IL\u20106 were measured as inflammation markers. A total of 69 patients (58% male and median age 62\u2009years) were enrolled in this study; 53.6% of total patients had oral <jats:italic>Candida<\/jats:italic> colonization. HsCRP and IL\u20106 levels were found to be significantly higher in the oral <jats:italic>Candida<\/jats:italic> colonization positive group than in the <jats:italic>Candida<\/jats:italic> colonization negative group (<jats:italic>P<\/jats:italic>\u2009=\u20090.002 and <jats:italic>P<\/jats:italic>\u2009=\u20090.01, respectively). HDL levels were significantly lower in the <jats:italic>Candida<\/jats:italic> colonization positive group (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Peripheral artery disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.05) and oral <jats:italic>Candida<\/jats:italic> colonization (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) were significantly associated with inflammation. In addition to conventional risk factors such as age (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), diabetes (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), and peripheral artery disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), oral <jats:italic>Candida<\/jats:italic> colonization is associated with coronary artery disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Oral <jats:italic>Candida<\/jats:italic> colonization might be associated with chronic inflammation and development of atherosclerosis in HD patients.<\/jats:p>","DOI":"10.1111\/1744-9987.12803","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T05:33:37Z","timestamp":1553146417000},"page":"542-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oral <i>Candida<\/i> Colonization as a Risk Factor for Chronic Inflammation and Atherosclerosis in Hemodialysis Patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-1048","authenticated-orcid":false,"given":"Hasan H","family":"Yeter","sequence":"first","affiliation":[{"name":"Department of Nephrology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Erten","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Sevmez","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Dentistry Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-5822","authenticated-orcid":false,"given":"Berfu","family":"Korucu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Kalkanci","sequence":"additional","affiliation":[{"name":"Department of Microbiology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehri","family":"Elbeg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Gazi University  Ankara 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