{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T17:46:04Z","timestamp":1748972764317,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to describe the safety profile and pharmacokinetic\/pharmacodynamic parameters in end\u2010stage renal disease patients who received gentamicin as empirical treatment in catheter\u2010related bacteremia when they showed infection signs, regardless of the timing of the next HD. Patients received gentamicin 3\u2009mg\/kg before blood culture extraction when they showed infection signs and regardless of the timing of next hemodialysis session. Serum concentrations were collected after the gentamicin administration (peak level) and before the next HD (trough level). Toxicities and adverse drug events were registered. The main pharmacokinetic\/pharmacodynamic goal for Gram\u2010negative infections was peak:minimum inhibitory concentration (MIC) \u226510. Sixteen patients were included. Nephrotoxicity was not assessed in this population, and no ototoxicity was found. According to microbial isolation and gentamicin susceptibility, the value of peak:MIC was 5.4\u2009\u00b1\u20092.0. The administration of gentamicin in these conditions was safe. Estimated pharmacokinetic values were consistent with previous studies and appropriate according to peak:MIC goal for Gram\u2010negative organisms with MIC \u22641\u2009mg\/L.<\/jats:p>","DOI":"10.1111\/1744-9987.12810","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T09:42:23Z","timestamp":1555148543000},"page":"550-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gentamicin as Empirical Treatment in Hemodialysis Patients: Safety, Pharmacokinetics, and Pharmacodynamics"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-9254","authenticated-orcid":false,"given":"Ana B","family":"Guisado\u2010Gil","sequence":"first","affiliation":[{"name":"Department of Pharmacy University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Herrera\u2010Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D","family":"Santos\u2010Rubio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Gil\u2010Sacaluga","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Microbiology and Preventive Medicine University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Lepe\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Microbiology and Preventive Medicine University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Camacho\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Microbiology and Preventive Medicine University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda V","family":"Gil\u2010Navarro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Hospital Virgen del Rocio  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G064"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q403"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2008.00554.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006286902"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.655774"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02920707"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006292987"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01762-12"},{"key":"e_1_2_6_10_1","first-page":"331","volume-title":"Applied Pharmacokinetic Principles of Therapeutic Drug Monitoring","author":"Zaske DE","year":"1992"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G420"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80811-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.6.627"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443030-00004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00819.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.1.93"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12458"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.05.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.2.236"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.26.040186.000455"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1995.tb05719.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70347-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.1.128"},{"key":"e_1_2_6_24_1","first-page":"1077","article-title":"Prediction of serum gentamicin concentrations in patients undergoing hemodialysis","volume":"37","author":"Goetz DR","year":"1980","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2012.672153"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1744-9987.12810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T17:37:21Z","timestamp":1694194641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/1744-9987.12810"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12810","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"type":"print","value":"1744-9979"},{"type":"electronic","value":"1744-9987"}],"subject":[],"published":{"date-parts":[[2019,6,27]]},"assertion":[{"value":"2018-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}