{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:50:09Z","timestamp":1783785009117,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010density lipoprotein apheresis (LDL\u2010A) has been used for nephrotic syndrome (NS) caused by focal segmental glomerulosclerosis in Japan. Idiopathic membranous nephropathy (iMN) can also cause treatment\u2010resistant NS. Therefore, we investigated the effect of LDL\u2010A during initial induction for it. This retrospective, observational, and single\u2010center study enrolled consecutive iMN patients who received steroids from March 2000 to May 2015. We compared data between 11 patients treated with LDL\u2010A (LDL\u2010A group) and 27 patients without (non\u2010LDL\u2010A group) at baseline and 4 and 8\u2009weeks later. Reduction rate of proteinuria and increase rate of serum albumin in LDL\u2010A group were significantly higher than the other after 4\u2009weeks (<jats:italic>P<\/jats:italic>\u2009=\u20090.036 and 0.030) and 8\u2009weeks (<jats:italic>P<\/jats:italic>\u2009=\u20090.030 and &lt;0.001), respectively. There was no adverse event caused by LDL\u2010A and immunosuppressant dose was not significantly different. In conclusion, LDL\u2010A may be an effective choice for initial induction of nephrotic iMN.<\/jats:p>","DOI":"10.1111\/1744-9987.12811","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T08:18:53Z","timestamp":1555489133000},"page":"575-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Low\u2010Density Lipoprotein Apheresis for Nephrotic Idiopathic Membranous Nephropathy as Initial Induction Therapy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-5468","authenticated-orcid":false,"given":"Eri","family":"Koshi\u2010Ito","sequence":"first","affiliation":[{"name":"Department of Nephrology Japanese Red Cross Nagoya Daini Hospital  Nagoya Japan"},{"name":"Department of Nephrology Fujita Health University School of Medicine  Toyoake 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