{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:38:33Z","timestamp":1781649513588,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T00:00:00Z","timestamp":1562457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Topical antibiotic and antiseptic agents have been documented to reduce exit\u2010site infection (ESI) and peritonitis in PD. The aim of this randomized controlled study was to evaluate the efficacy of polyhexanide in the prevention of ESI and peritonitis. Patients were excluded if they had active infection, &gt; 18 years of age, ESI and peritonitis within the previous 4 weeks, received PD for less than 3\u2010months and history of allergy to either drug. All patients were followed up until catheter removal, death, switch to dialysis, transplantation or the end of the study. ESI, tunnel infection, peritonitis, catheter removal and microorganism cause of catheter\u2010related infection were recorded prospectively during clinic follow\u2010up. A total of 88 patients (41 povidone\u2010iodine group; 47 polyhexanide group) were enrolled with a total follow\u2010up duration of 480 and 555 patient\u2010months for povidone\u2010iodine and alternating group, respectively. There were no significant differences in the age, sex, BMI, time of PD, rate of DM, and <jats:italic>S. aureus<\/jats:italic> carriage state. A total of 8 ESI and 25 peritonitis episodes were detected during the study. ESI and peritonitis rates tended to be lower in polyhexanide group compared with the povidone\u2010iodine group (0.06 episodes\/patient\u2010year vs. 0.12 episodes\/patient\u2010year; 0.26 episodes\/patient\u2010year vs. 0.32 episodes\/patient\u2010year, respectively), but were not significant statistically. Moreover, catheter removal was similar in both groups (0.04 \/ patient\u2010year vs. 0.05 \/ patient\u2010year). Polyhexanide is efficient and safe for the prevention of ESI and peritonitis and it may be used as an alternative procedure for the care of healthy exit sites.<\/jats:p>","DOI":"10.1111\/1744-9987.12836","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T15:05:13Z","timestamp":1557327913000},"page":"81-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Local Polyhexanide Application in Preventing Exit\u2010Site Infection and Peritonitis: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-5157","authenticated-orcid":false,"given":"Mevlut","family":"Ceri","sequence":"first","affiliation":[{"name":"Department of Nephrology Pamukkale University Faculty of Medicine  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seref Rahmi","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selman","family":"Unverdi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sanko University Faculty of Medicine  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhan","family":"Kurultak","sequence":"additional","affiliation":[{"name":"Department of Nephrology Trakya University Faculty of Medicine  Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Duranay","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ankara Education and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp411"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090773"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080802800514"},{"key":"e_1_2_6_6_1","first-page":"103","article-title":"Use of sodium hypochlorite in peritoneal dialysis: the genesis of the 'Y' set and beyond","volume":"154","author":"Buoncristiani U","year":"2007","journal-title":"Contrib Nephrol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318264"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.14.1041"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502500203"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00049"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00109"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02079-12"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2017.03.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00091"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1744-9987.12836","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:14:49Z","timestamp":1694135689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,7]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/1744-9987.12836"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12836","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,7]]},"assertion":[{"value":"2019-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}