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Ten main iron formulations are recognized (with clear differences in composition and possible reactions of intolerance and anaphylaxis), which are indicated for iron deficiency anemia, including nephropathic subjects, as suggested by medical guidelines. With some types of iron formulation (especially iron carboxymaltose) a particular side effect has been observed: hypophosphatemia, mediated by FGF23. This review aims to draw attention to this correlation and the contradiction represented by the presence of both positive and negative modulation by FGF23, with the effects induced by its increase even after long\u2010term treatment with iron formulation. However, more evidence is needed to understand the reasons for this differential stimulation.<\/jats:p>","DOI":"10.1111\/1744-9987.13435","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T16:30:35Z","timestamp":1567614635000},"page":"258-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Iron Infusion and Induced Hypophosphatemia: The Role of Fibroblast Growth Factor\u201023"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-0681","authenticated-orcid":false,"given":"Giuseppe","family":"Coppolino","sequence":"first","affiliation":[{"name":"Renal Unit, Department of Health Sciences \u201cMagna Graecia\u201d University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Nicotera","sequence":"additional","affiliation":[{"name":"Renal Unit, Department of Health Sciences \u201cMagna 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