{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:50:26Z","timestamp":1777639826868,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The efficacy and safety of zinc acetate hydrate (ZAH) for zinc supplementation in patients on maintenance hemodialysis (MHD) remains unknown. In this prospective, single\u2010center, open\u2010label, parallel\u2010group trial for MHD patients with serum zinc level &lt;70\u2009\u03bcg\/dL, we compared ZAH (zinc; 50\u2009mg\/day) and polaprezinc (PPZ; zinc; 34\u2009mg\/day) beyond 6\u2010month administration in a 1:1 randomization manner. The ZAH and PPZ groups had 44 and 47 patients, respectively. At 3 months, the change rate of serum zinc levels in the ZAH group was significantly higher than that in the PPZ group. Three months after the study, serum copper levels significantly decreased in the ZAH group, but not in the PPZ group. No significant differences were noted in anemia management in either group. ZAH was superior to PPZ in increasing serum zinc levels. Clinicians should note the stronger decline in serum copper levels when using ZAH for MHD patients.<\/jats:p>","DOI":"10.1111\/1744-9987.13461","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T15:38:01Z","timestamp":1575387481000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single\u2010center, open\u2010label, prospective randomized study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-3811","authenticated-orcid":false,"given":"Teppei","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Urology Oyokyo Kidney Research Institute Aomori Hospital  Aomori Japan"},{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Hatakeyama","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Oyokyo Kidney Research Institute Aomori Hospital  Aomori Japan"},{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Urology Oyokyo Kidney Research Institute Aomori Hospital  Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tooru","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Urology Oyokyo Kidney Research Institute Aomori Hospital  Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitada","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Urology Oyokyo Kidney Research Institute Aomori Hospital  Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Oyokyo Kidney Research Institute  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00212-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053783"},{"key":"e_1_2_8_4_1","first-page":"427","article-title":"Smell and taste disorders: A primary care approach","volume":"61","author":"Bromley SM","year":"2000","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6490349"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0182"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-014-0121-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.959412"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017050492"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.117.1093"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"22","article-title":"Proposal of the clinical standard value for diagnose of zinc deficiency by serum zinc value","volume":"19","author":"Tomita HA","year":"2008","journal-title":"Biomed Res Trace Elem"},{"key":"e_1_2_8_12_1","first-page":"96e\u20109","volume-title":"Harrison's Principles of Internal Medicine","author":"Robert R","year":"2015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.4.777"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1569-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-018-0155-x"},{"key":"e_1_2_8_16_1","unstructured":"SinghP NeeJ. 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