{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:38:45Z","timestamp":1777498725276,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>ABO antigens play an important role in solid organ transplantation. Desensitization for ABO incompatibility offers patients awaiting transplant a larger donor pool. The aim of this study was to assess outcome of desensitization using the institutional preconditioning protocol in ABO\u2010incompatible solid organ transplants. A retrospective analysis of ABO\u2010incompatible solid organ transplants between October 2015 and June 2018, at a tertiary healthcare center was performed. The preconditioning regimen consisted of immunosuppression and therapeutic apheresis (TA). Pre\u2010 and post\u2010TA titers were performed, until a target titer of 8 or below was achieved, at which transplant was performed. Follow\u2010up data till 1\u2009year was analyzed. A total of 50 ABO\u2010incompatible solid organ transplantations, including 14 liver transplants and 36 renal transplants were analyzed. The median baseline anti\u2010A and anti\u2010B titers were 192 and 256, respectively. A total of 150 therapeutic plasma exchange (TPE) procedures were performed for renal transplant recipients; 19 TPE and eight immunoadsorption procedures (five preoperative and three intraoperative) were performed for liver transplant recipients. Five (10%) patients experienced minor adverse events. Biopsy revealed antibody\u2010mediated rejection was observed in three cases in the immediate posttransplant phase and in three (6.67%) cases over 1\u2009year. There was one death due to transplant\u2010associated thrombotic microangiopathy. Graft survival for renal transplant was 100% and death\u2010censored graft survival for liver transplant was 100%. Despite difficulties, ABO\u2010incompatible transplants can be performed without antibody\u2010mediated rejection with the use of an appropriate protocol.<\/jats:p>","DOI":"10.1111\/1744-9987.13495","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T05:09:54Z","timestamp":1586322594000},"page":"103-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic apheresis in <scp>ABO<\/scp>\u2010incompatible kidney and liver transplantation: A single\u2010center experience of 50 patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-8152","authenticated-orcid":false,"given":"Prashant","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Histocompatibility and Molecular Biology Jaypee Hospital  Noida 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