{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:39:43Z","timestamp":1785451183507,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005771","name":"Dokuz Eyl\u00fcl \u00dcniversitesi","doi-asserted-by":"publisher","award":["2017.KB.SAG.015"],"award-info":[{"award-number":["2017.KB.SAG.015"]}],"id":[{"id":"10.13039\/501100005771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peritoneal fibrosis (PF) is a pathological change that occurs mostly long\u2010term peritoneal dialysis (PD) patients, as a result of triggering the inflammatory response. Plasminogen activator inhibitor\u20101 (PAI\u20101) is an important molecule featured in the development of fibrosis. It has been shown in literature that PAI\u20101 gene alterations are associated with fibrosis in many tissues and organs. However, PAI\u20101 gene alterations in long\u2010term PD patients have not yet been investigated. In this study, PAI\u20101 4G\/5G polymorphism was examined by reverse hybridization, and all coding exons of the PAI\u20101 gene were examined by sequence analysis to provide treatment modification in patients with predisposition before fibrosis develops. The patients were divided into two groups according to ultrafiltration failure test and duration of PD treatment: those with suspected PF or a high probability of developing PF (36%) and those with a low probability of developing PF (64%). There was no significant difference between the two groups in findings such as peritoneal equilibration test (PET), Kt\/V, the content of the PD solution used, peritonitis, and PAI\u20101 4G\/5G polymorphism (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). A total of eight gene alterations (rs2227660, rs2227668, rs2854233, rs41281004, rs61553169, rs368413856, rs2227684) were detected by sequence analysis, one of which was exonic (rs6092). When the genotype distributions of these variants were examined, no significant difference was found between the two groups. PAI\u20101 gene changes were not detected in patients with the probability of developing PF. There is a need for further studies involving other molecules responsible for predisposing to PF with larger patient populations in patients undergoing long\u2010term PD treatment.<\/jats:p>","DOI":"10.1111\/1744-9987.13501","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T06:19:05Z","timestamp":1587104345000},"page":"97-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between plasminogen activator inhibitor\u20101 gene alterations and fibrosis in peritoneal dialysis patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-8047","authenticated-orcid":false,"given":"Duygu","family":"Onur Cura","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Medical Genetics Dokuz Eylul University  Izmir 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