{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T10:26:00Z","timestamp":1775989560057,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u201cConventional exchange transfusion\u201d\u2014that delivers nondescript \u201cstandard issue\u201d units of red blood cells (RBCs)\u2014is used worldwide to rescue dying <jats:italic>Plasmodium falciparum (Pf)<\/jats:italic> malaria patients. Recently, exchanging special malaria\u2010resistant RBCs (T\u2010REX) has been recommended to prevent random delivery of malaria\u2010susceptible RBCs that promote <jats:italic>Pf<\/jats:italic> infection. Fortunately, Papua New Guinea (PNG) is well positioned to help optimize exchange as \u201ca rescue adjunct\u201d because (a) Gerbich\u2010negative (GN) RBCs that resist <jats:italic>Pf<\/jats:italic> invasion are prevalent in PNG; (b) with international support, PNG has conducted outstanding malaria research; (c) PNG's scientists feel studies of GN RBCs can advance malaria therapeutics; and (d) with blood\u2010bank support, evaluating exchange of GN RBCs is feasible in PNG. An exchange\u2010transfusion study of GN RBCs might attract international sponsorship given the threat of expanding drug\u2010resistance as well as growing recognition that advancing transfusion medicine and expanding blood donation could especially help <jats:italic>Pf<\/jats:italic>\u2010infected children\u2014immediately.<\/jats:p>","DOI":"10.1111\/1744-9987.13551","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T06:50:50Z","timestamp":1592808650000},"page":"242-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Therapeutically\u2010rational exchange (T\u2010REX) of Gerbich\u2010negative red blood cells can be evaluated in Papua New Guinea as \u201ca rescue adjunct\u201d for patients with <i>Plasmodium falciparum<\/i> malaria<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-7635","authenticated-orcid":false,"given":"Ryan Philip","family":"Jajosky","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"},{"name":"Biconcavity Inc.  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