{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:44:29Z","timestamp":1779101069547,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effectiveness of monitoring serum carnitine levels in hemodialysis patients receiving <jats:sc>L<\/jats:sc>\u2010carnitine supplementation. One\u2010hundred forty\u2010five hemodialysis patients were divided into three groups. Group 1 consisted of patients (<jats:italic>n<\/jats:italic>\u00a0=\u200930) who had been receiving supplementation before this study and then discontinued at the beginning. The remaining patients were divided into Group 2 (<jats:italic>n<\/jats:italic>\u00a0=\u200913) and Group 3 (<jats:italic>n<\/jats:italic>\u00a0=\u2009102) based on their baseline free carnitine (FC) level, &lt;20 or\u2009\u2265\u200920\u2009\u03bcmol\/L. Group 2 was started on supplementation, and Groups 1 and 3 were observed without any intervention for the first 6\u2009months. FC was measured every 6\u2009months in all three groups up to 18\u2009months. All patients in whom FC was less than 20\u2009\u03bcmol\/L at 6 and 12\u2009months were prescribed supplementation. After the first 6\u2009months, the mean\u2009\u00b1\u2009<jats:italic>SD<\/jats:italic> of FC changed from 262.5\u2009\u00b1\u200987.5\u2009\u03bcmol\/L at baseline to 70.8\u2009\u00b1\u200933.6\u2009\u03bcmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) in Group 1, from 17.4\u2009\u00b1\u20091.9 to 193.9\u2009\u00b1\u200943.3\u2009\u03bcmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) in Group 2, and from 49.2\u2009\u00b1\u200924.6 to 44.2\u2009\u00b1\u200919.8\u2009\u03bcmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05) in Group 3. The acyl\/free carnitine changed from 0.62 to 0.59 in Group 1 (<jats:italic>P<\/jats:italic>\u00a0=\u20090.287), from 0.76 to 0.66 in Group 2 (<jats:italic>P<\/jats:italic>\u00a0=\u20090.054) and from 0.57 to 0.60 in Group 3 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05). Of the 145 patients, 126 continued follow\u2010up for the full 18\u2009months. FC remained in the normal range (36\u201374\u2009\u03bcmol\/L) within the 95% CI. FC was considered a strong predictor of carnitine deficiency after 6\u2009months (AUC: 0.9146, cut\u2010off value: 33.8\u2009\u03bcmol\/L). FC monitoring is essential for appropriate carnitine supplementation in hemodialysis patients.<\/jats:p>","DOI":"10.1111\/1744-9987.13621","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T14:53:28Z","timestamp":1611154408000},"page":"595-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of monitoring free carnitine levels for <scp>L<\/scp>\u2010carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-1812","authenticated-orcid":false,"given":"Etsuko","family":"Kumagai","sequence":"first","affiliation":[{"name":"Kenwakai Hospital  Iida Japan"},{"name":"Department of Innovative Medicine Osaka Medical College  Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Hosohata","sequence":"additional","affiliation":[{"name":"Education and Research Center for Clinical Pharmacy Osaka University of Pharmaceutical Sciences  Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Furumachi","sequence":"additional","affiliation":[{"name":"Kenwakai Hospital  Iida Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Innovative Medicine Osaka Medical College  Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.03.070183.001313"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V133708"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00110-0"},{"key":"e_1_2_7_5_1","unstructured":"http:\/\/www.jpeds.or.jp\/uploads\/files\/20181207_shishin.pdf. 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