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The therapeutic effect of plasma exchange on thrombotic microangiopathies has been established. We present three clinical cases in the intensive care unit that illustrate continuous plasma exchange with dialysis as a flexible blood purification therapy for critically ill patients; a radical treatment, thrombotic microangiopathies; supportive therapy, multiple organ failure; and fluid balance regulator. The retrospective analysis of 13 continuous plasma exchange with dialysis sessions showed that the platelet count increased significantly (<jats:italic>p\u2009=<\/jats:italic>\u00a00.0096) after its administration. The total protein, albumin, fibrinogen, or calcium did not decrease significantly after continuous plasma exchange with dialysis, suggesting therapeutic efficacy and fewer adverse events. A prospective study on thrombotic microangiopathies for continuous plasma exchange with dialysis is currently underway.<\/jats:p>","DOI":"10.1111\/1744-9987.13654","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T18:46:16Z","timestamp":1619117176000},"page":"377-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Continuous plasma exchange with dialysis for thrombotic microangiopathy in intensive care unit: Retrospective observational study"],"prefix":"10.1111","volume":"25","author":[{"given":"Kasumi","family":"Satoh","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Akita University 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