{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:19:50Z","timestamp":1782587990469,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many reports have shown the therapeutic efficacy of LDL apheresis (LDL\u2010A) in drug\u2010resistant nephrotic syndrome (NS) for improvement of heavy proteinuria and severely impaired renal function. To obtain comprehensive results in a large number of cases, a post hoc analysis of the Prospective Observational survey on the Long\u2010Term Effects of the LDL\u2010Apheresis on the Drug Resistant Nephrotic Syndrome (POLARIS) study was performed by stratifying enrolled cases according to the pretreatment estimated glomerular filtration rate (eGFR) levels indicating normal (N) (\u226560\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>), moderately impaired (M) (\u226530 to &lt;60\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>), and severely impaired (S) (&lt;30\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>) renal function. Significant improvements of proteinuria and renal function were found in Group N and, most interestingly, in Group M. A tendency for improvement in proteinuria was found in Group S. Most cases in all groups had not entered end\u2010stage renal disease at 2\u2009years after LDL\u2010A treatment. These results suggest that LDL\u2010A has therapeutic efficacy even in cases in which renal function has declined to 30\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/1744-9987.13694","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T11:47:06Z","timestamp":1622461626000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Favorable therapeutic efficacy of low\u2010density lipoprotein apheresis for nephrotic syndrome with impaired renal function"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1150-7419","authenticated-orcid":false,"given":"Eri","family":"Muso","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Faculty of Contemporary Home Economics Kyoto Kacho University  Kyoto Japan"},{"name":"Department of Nephrology and Dialysis Kitano Hospital, Tazuke Kofukai Medical 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