{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:27:51Z","timestamp":1762432071316,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Infants with acute kidney injury (AKI) who are critically ill often will have multiorgan dysfunctions. Objective of the present study was to find out mortality, recovery of kidney function at discharge and at 3\u00a0months, and to determine risk factors for mortality. Fifty\u2010two infants (24 newborns and 28 postneonatal) with AKI were included. Staging was done as per Kidney Disease Improving Global Outcomes classification. Patients were subjected to medical treatment and peritoneal dialysis (PD), wherever indicated. Kidney function tests were performed at admission, discharge, and at 3\u00a0months follow\u2010up. Median age of neonates was 8\u2009days and postneonatal infants were 4.5\u00a0months. Stage 1, 2, and 3 AKI were present in 14 (26.9%), 16 (30.7%), and 22 (42.3%) cases, respectively. PD was required in 22 (42.3%) infants, and significantly higher in postneonatal than in neonates (57.1% vs. 25%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Significant recovery of kidney function occurred at discharge and cases had normal parameters at 3\u00a0months. Mortality was 17.3%. Patients had significantly higher risk of mortality, if they had metabolic acidosis (OR 13.22, CI 2.33\u201374.94, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and needed ventilation (OR 14.93, 95% CI 1.7\u2013130.97, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) and PD (OR 6.53, 95% CI 1.20\u201335.48, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026). In logistic regression analysis, fluid overload (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009001), hypotension (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and higher PRISM\u2010III score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) were found as significant risk factors for mortality. Medical management including PD led to good recovery of kidney function. Presence of fluid overload, hypotension, and higher PRISM\u2010III score adversely affected the outcome.<\/jats:p>","DOI":"10.1111\/1744-9987.13712","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T03:04:20Z","timestamp":1627009460000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for mortality in critically ill infants with acute kidney injury: A resource\u2010limited setting experience"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-7392","authenticated-orcid":false,"given":"Om P.","family":"Mishra","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avdhesh Kumar","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Abhinay","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akanksha","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajniti","family":"Prasad","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92057-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(17)30069-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611391"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.235172"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1541-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00211"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.05.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00118"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-012-0791-z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00254"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820975897"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12660"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-019-03150-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345186"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050672"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2021.1874201"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00322-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.11.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-020-1815-9"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.10.048"},{"issue":"1","key":"e_1_2_8_22_1","first-page":"107","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. 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