{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:42:19Z","timestamp":1780627339863,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with sepsis are prone to fluid overload (FO) due to fluid resuscitation, irrespective of stage of acute kidney injury (AKI). The aim of our study was to analyze the association between FO at continuous renal replacement therapy (CRRT) initiation and 28\u2010day mortality in patients with sepsis associated AKI (S\u2010AKI). In this retrospective study, data for patient characteristics were collected and 28\u2010day mortality were studied. We also analyze association of variables, including FO degrees with 28\u2010day mortality. Earlier commencement of CRRT showed better outcome. Non\u2010survivors had higher FO than survivor (9.17% vs. 5.20%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). Survival in patients with FO\u2009&gt;\u200910% over 28\u2009days was significantly worse compared to those with FO\u2009\u2264\u200910% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006). Multivariate analysis showed, FO\u2009&gt;\u200910% (95%CI [1.721, 17.195], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) was significantly associated with increased 28\u2010day mortality. In S\u2010AKI requiring CRRT, FO\u2009&gt;\u200910% at CRRT initiation was independently associated with 28\u2010day mortality.<\/jats:p>","DOI":"10.1111\/1744-9987.13727","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T15:30:39Z","timestamp":1629991839000},"page":"288-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased 28\u2010day mortality due to fluid overload prior to continuous renal replacement in sepsis associated acute kidney injury"],"prefix":"10.1111","volume":"26","author":[{"given":"Junjun","family":"Fang","sequence":"first","affiliation":[{"name":"Intensive Care Unit The First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhejiang Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhejiang Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Cui","sequence":"additional","affiliation":[{"name":"Intensive Care Unit The First Affiliated Hospital, College of Medicine, Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-6621","authenticated-orcid":false,"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhejiang Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3934-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2112-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-06067-1_29"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.159"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1085-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1355-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003862"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.8.1337"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172137"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000544"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000268"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"e_1_2_8_16_1","first-page":"CD010612","article-title":"Timing of renal replacement therapy initiation for acute kidney injury","volume":"12","author":"Fayad AII","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5828"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803213"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2000741"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002189"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4989-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2007.12.017"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11682"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00358-3"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.13727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1744-9987.13727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.13727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:48:50Z","timestamp":1693140530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.13727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/1744-9987.13727"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.13727","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]},"assertion":[{"value":"2021-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}