{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:57:41Z","timestamp":1754485061323,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Acute kidney injury (AKI) is a common diagnosis in hospitalized patients. Dialysis requiring AKI (AKI\u2010D) is associated with adverse outcomes. This study aims to know the clinical profile and short\u2010term outcomes at 3\u2009months, in patients with AKI\u2010D, at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational study was done of all the patients admitted with AKI\u2010D for 2\u2009years, from July 2018 to June 2020. We recorded clinical parameters at baseline and postdischarge follow\u2010up at 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010eight patients had AKI\u2010D over 2\u2009years. Then, 116 (90.6%) patients had community\u2010acquired AKI (CAAKI), and 12 (9.4%) patients had hospital\u2010acquired AKI. The underlying causes of AKI\u2010D were: toxins in 48 (37.5%), sepsis in 31 (24.2%), acute kidney disease in 15 (11.7%), acute gastroenteritis (AGE) in 9 (7%), and cardiogenic shock in 7 (5.5%) patients. The mean values of intact parathyroid hormone (available in 32% of patients) were 268\u2009pg\/mL. Intermittent hemodialysis was the commonest mode of dialysis (85.2%). A kidney biopsy was done in 23 (18%) patients. The most common diagnosis on kidney biopsy was glomerulonephritis (GN) in 12 patients (crescentic GN\u20109 and IgA nephropathy\u20103), followed by acute tubule\u2010interstitial nephritis in 6 patients. In\u2010hospital mortality was 29.7%. Overall, 39% regained serum creatinine in the normal range at 3\u2009months, 36.7% died, 14.1% reached chronic kidney disease (CKD), 7.8% lost to follow\u2010up, and 2.3% had reached end\u2010stage renal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of AKI\u2010D at our center was CAAKI. A significant chunk of AKI\u2010D (68.7%) was caused by preventable causes like toxins, sepsis, and AGE. Dysregulation of mineral metabolism was conspicuous. In chemical toxin vs. biological toxins and undifferentiated sepsis vs. the identifiable cause of sepsis, formers had significantly more in\u2010hospital mortality than the latter ones. AKI\u2010D is associated with high in\u2010hospital mortality, total mortality, and risk of progression to CKD at 3\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13739","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T11:43:51Z","timestamp":1632051831000},"page":"594-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology and outcomes of dialysis requiring acute kidney injury: A <scp>single\u2010center<\/scp> study"],"prefix":"10.1111","volume":"26","author":[{"given":"Ajay","family":"Jaryal","sequence":"first","affiliation":[{"name":"Department of Nephrology Indira Gandhi Medical College  Shimla Himachal Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-0384","authenticated-orcid":false,"given":"Sanjay","family":"Vikrant","sequence":"additional","affiliation":[{"name":"Department of Nephrology Indira Gandhi Medical College  Shimla Himachal Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalip","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine Indira Gandhi Medical College  Shimla Himachal Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","journal-title":"Kidney 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