{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:12:39Z","timestamp":1758125559728,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Vaccines generally have reduced effectiveness in hemodialysis patients and a similar condition may also apply for the SARS\u2010CoV\u20102 vaccines. The aim of this study was to analyze humoral responses of hemodialysis patients to SARS\u2010CoV\u20102 vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010five maintenance hemodialysis patients who received either inactivated or mRNA SARS\u2010CoV\u20102 vaccines were investigated. Antibody levels were measured by a commercial antibody kit, which detected antibodies toward receptor binding domain of the SARS\u2010CoV\u20102 spike protein. Comparative analyzes were carried between vaccine groups and with a control group of 103 healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seropositivity rate and antibody levels were significantly lower in hemodialysis patients who received inactivated vaccine (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.000). While mRNA vaccine had better immunogenicity, both vaccines protected from symptomatic infection when seropositivity was achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusion<\/jats:title><jats:p>When used in the same dose with the general population, inactivated SARS\u2010CoV\u20102 vaccines generate reduced humoral response in hemodialysis patients. mRNA vaccines have better immunogenicity in this group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13752","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T03:39:17Z","timestamp":1636169957000},"page":"769-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antibody responses to the <scp>SARS\u2010CoV<\/scp>\u20102 vaccines in hemodialysis patients: Is inactivated vaccine effective?"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-2914","authenticated-orcid":false,"given":"Ahmet","family":"Murt","sequence":"first","affiliation":[{"name":"Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Nephrology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet R\u0131za","family":"Altiparmak","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Nephrology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Yadigar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Dr Lutfi Kirdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan Feyyaz","family":"Yalin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Dr Lutfi Kirdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dogukan","family":"Ozbey","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty, Department of Medical Microbiology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry Dr Lutfi Kirdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Kocazeybek","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty, Department of Medical Microbiology Istanbul University\u2010Cerrahpasa  Istanbul 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.01.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020040470"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13531"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.08.032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168436"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2007.00283.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3199"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01429-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.603058"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03700321"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab179"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.04.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abj1031"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab193"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027906"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30987-7"}],"container-title":["Therapeutic 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