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Based on published reports, therapeutic plasma exchange has generally been employed as rescue or adjunctive therapy in patients with critical illness, with proposed benefit attributed possible effects on mitigation and amelioration of cytokine storm syndrome. Treatment effects remain uncertain, with the impact of plasma exchange on critical illness in COVID inconclusive with regard to both efficacy and safety.<\/jats:p>","DOI":"10.1111\/1744-9987.13779","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T09:39:49Z","timestamp":1670233189000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of therapeutic plasma exchange in <scp>COVID<\/scp>\u201019: A systematic review of current evidence"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-470X","authenticated-orcid":false,"given":"Nicholas","family":"Carlson","sequence":"first","affiliation":[{"name":"Department of Nephrology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-6077","authenticated-orcid":false,"given":"Wladimir 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