{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:32:01Z","timestamp":1760524321963,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Hyponatremia is a common electrolyte disturbance in critically ill patients. Management of intensive care unit patients with concurrent hyponatremia and renal failure requiring dialysis is challenging especially with regional citrate anticoagulation, which may cause excessive rise of serum [Na+<\/jats:sup>]. We described the first and successful modified continuous veno\u2010venous hemodialysis (CVVHD) regimen using regional citrate anticoagulation.<\/jats:p><\/jats:sec>Method<\/jats:title>A mathematical model was developed to predict serum [Na+<\/jats:sup>] change during CVVHD. Our in\u2010house CVVHD regimen using regional citrate anticoagulation was modified to slow down the rise of serum [Na+<\/jats:sup>] by both modifying the dialysate solution and modifying the circuit.<\/jats:p><\/jats:sec>Result<\/jats:title>Five out of six patients had gradual serum [Na+<\/jats:sup>] correction not exceeding the daily limit. None of them developed osmotic demyelination syndrome.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We concluded that regional citrate anticoagulation, with proper modification, is safe and effective for patients with concomitant renal failure requiring hemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13808","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T17:57:54Z","timestamp":1643911074000},"page":"1114-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correction of severe hyponatremia by continuous veno\u2010venous hemodialysis with regional citrate anticoagulation: A case series"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-3624","authenticated-orcid":false,"given":"Kin Ho Steven","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Intensive Care Tuen Mun Hospital Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Tuen Mun Hospital Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"King\u2010Chung","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Tuen Mun Hospital Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"163","article-title":"Incidence and etiology of hyponatremia in an intensive care unit","volume":"34","author":"Devita MV","year":"1990","journal-title":"Clin Nephrol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1111\/eci.12123"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1038\/ki.2009.251"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1097\/00005792-199311000-00001"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1007\/s00134-014-3210-2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1016\/j.xkme.2020.05.007"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1016\/j.ekir.2018.09.001"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.2215\/CJN.13281117"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1111\/aas.13798"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1001\/jama.2020.18618"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1172\/JCI103712"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1080\/08860220701392314"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.13808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1744-9987.13808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.13808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:32:21Z","timestamp":1692621141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.13808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/1744-9987.13808"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.13808","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"type":"print","value":"1744-9979"},{"type":"electronic","value":"1744-9987"}],"subject":[],"published":{"date-parts":[[2022,2,14]]},"assertion":[{"value":"2021-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}