{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:53:32Z","timestamp":1789750412905,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to compare the efficacy and safety of citrate and heparin in continuous renal replacement therapy (CRRT) for critically ill patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Searched in PubMed, Embase, and Cochrane Library databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses showed that there no difference existed in mortality, metabolic alkalosis, circuit loss, and the number of transfused between the two groups (RR\u00a0=\u00a00.95, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.40; RR\u00a0=\u00a01.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.40; RR\u00a0=\u00a00.64, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.09; RR\u00a0=\u00a01.05, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.70). The filter life of the citrate group was longer than the heparin group (MD\u00a0=\u00a016.98, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The risk of bleeding and heparin\u2010induced thrombocytopenia was significantly lower in the citrate (RR\u00a0=\u00a00.32, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001; RR\u00a0=\u00a00.55, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). The citrate group was more susceptible to hypocalcemia (RR\u00a0=\u00a04.85, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Citrate anticoagulant therapy should have priority for CRRT in most critically ill patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13850","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T10:31:10Z","timestamp":1649241070000},"page":"1086-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4453-9166","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"first","affiliation":[{"name":"Weifang Medical 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