{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:51Z","timestamp":1747182531142,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Peritoneal fibrosis may progress in peritoneal dialysis (PD) patients to a fatal clinical condition called encapsulating peritoneal sclerosis (EPS). Transforming growth factor (TGF)\u2010\u03b2 plays a pivotal role in the pathogenesis of peritoneal fibrosis. We aimed to investigate the association among polymorphisms in the gene encoding <jats:italic>TGF\u2010\u03b21<\/jats:italic>, which were \u2212509C\/T (rs1800469), +869T\/C (rs1982073), and +915G\/C (rs1800471) in EPS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 16 PD patients who were clinically and radiologically diagnosed with EPS were enrolled and 22 age\u2010 and gender\u2010matched PD patients were selected as the non\u2010EPS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>G allele frequency at the rs1800471 gene polymorphism was significantly higher in the EPS group than non\u2010EPS group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). Interestingly, the non\u2010EPS group patients had CC or CG polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>C allele in <jats:italic>TGF\u2010\u03b21<\/jats:italic> rs1800471 gene polymorphisms might indicate a protective feature in EPS development. Knowing the presence of polymorphism may be effective in selecting renal replacement therapy in patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13913","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T10:29:16Z","timestamp":1659436156000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["C allele in transforming growth factor\u2010\u03b21 rs1800471 gene polymorphisms might indicate a protective feature in encapsulating peritoneal sclerosis development"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-2090","authenticated-orcid":false,"given":"Feyza","family":"Bora","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengisu","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-3299","authenticated-orcid":false,"given":"Fatih","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Nephrology Antalya Atat\u00fcrk State Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fettah Fevzi","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadi","family":"K\u00f6ksoy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahat","family":"\u00d6zdem","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Medical Biochemistry Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130kbal \u00d6zen","family":"K\u00fc\u00e7\u00fck\u00e7etin","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Medical Biochemistry Akdeniz University Medical School  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Sipahio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Erciyes University Medical School  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology \u00c7ukurova University Medical School  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yener","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Cumhuriyet University Medical School  Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Memnune Sena","family":"Ulu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Nephrology Bah\u00e7e\u015fehir University Medical School  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006111292"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"S30","article-title":"Morphological aspects of peritoneal sclerosis","volume":"14","author":"Garosi G","year":"2001","journal-title":"J Nephrol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2016.10.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502504S04"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112050"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080402400414"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.07.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2015.08.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2016.0382"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199810270-00009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01150.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-007-0337-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428319869096"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.03.040"},{"key":"e_1_2_8_16_1","first-page":"CD007554","article-title":"Biocompatible dialysis fluids for peritoneal dialysis","volume":"3","author":"Cho Y","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12048"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2007.00538.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109778"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004060436"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.12.035"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.090"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00461"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.436"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs289"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111197"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2007.00473.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00357.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701741684"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00049"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13501"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP62455"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013488"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232937"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-01977-1"},{"issue":"4","key":"e_1_2_8_36_1","first-page":"233","article-title":"Transforming growth factor\u2010\u03b21 gene polymorphism rs1800471 and end\u2010stage renal disease Br","volume":"78","author":"Almukhtar S","year":"2021","journal-title":"J Biomed Sci"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3182a32e24"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.02.017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp079"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31826c5508"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-14-66"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_598_19"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1419"},{"issue":"4","key":"e_1_2_8_44_1","first-page":"137","article-title":"Is there any association between mycosis fungoides and Th\u20101, Th\u20102 cytokines and transforming growth factor\u2010beta 1 gene polymorphisms?","volume":"52","author":"Yazici S","year":"2018","journal-title":"Turkderm Turk Arch Dermatol Venereol"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2015.0301"},{"issue":"2","key":"e_1_2_8_46_1","first-page":"173","article-title":"TNF\u2010alpha, TGF\u2010beta, IL\u201010, IL\u20106 and IFN\u2010gamma gene polymorphisms as risk factors for brucellosis","volume":"32","author":"Karaoglan I","year":"2009","journal-title":"New Microbiol"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.07.019"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364301"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"issue":"145","key":"e_1_2_8_50_1","first-page":"271","article-title":"MicroRNAs in peritoneal fibrosis: a systematic review","volume":"26","author":"Yanai K","year":"2018","journal-title":"Discov Med"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.13913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1744-9987.13913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.13913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T23:44:14Z","timestamp":1692402254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.13913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/1744-9987.13913"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.13913","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"type":"print","value":"1744-9979"},{"type":"electronic","value":"1744-9987"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"assertion":[{"value":"2022-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}