{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:55:03Z","timestamp":1789664103506,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Low\u2010density lipoprotein (LDL) apheresis is a treatment option for patients with unhealed chronic limb\u2010threatening ischemia (CLTI) after revascularization. The newly developed AS\u201025 is a direct hemoperfusion\u2010type apheresis device that differs from conventional LDL apheresis therapy and is designed to specifically adsorb both LDL\u2010C and fibrinogen. We evaluate the efficacy and safety of AS\u201025.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 61 patients whose ulcers failed to heal after revascularization or were ineligible for revascularization. Of these, 50 were undergoing hemodialysis. The primary endpoint was the healing rate of a target\u00a0lesion of interest (ulcer), using historical data as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ulcer healing rate of 45.9% was significantly higher than the historical data. No significant safety concerns were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AS\u201025 was effective in healing ulcers and preventing major amputation even in CLTI refractory patients on hemodialysis, thus showing potential clinical applicability and high significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>UMIN study ID UMIN000020336.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13915","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T14:40:09Z","timestamp":1659451209000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A novel low\u2010density lipoprotein\/fibrinogen apheresis method for chronic limb\u2010threatening ischemia in patients with poor options for revascularization: A multicenter, single\u2010arm clinical trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-814X","authenticated-orcid":false,"given":"Shuzo","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Kidney Disease and Transplant Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Oita Oka Hospital  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Ichioka","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Saitama Medical University  Moroyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Sapporo City General Hospital  Sapporo 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