{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:28:56Z","timestamp":1747182536122,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["19A\u20102014","21A\u20102002"],"award-info":[{"award-number":["19A\u20102014","21A\u20102002"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dialysis patients have a 10\u201325 times higher risk of reactivation of tuberculosis (TB). In this study, we investigated the diagnostic ability of QuantiFERON (QFT)\u2010plus for TB in hemodialysis patients. QFT\u2010plus, an interferon gamma release assay, is characterized by its use of CD4 and CD8 T cell signals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hemodialysis patients aged 20\u2009years or older who underwent QFT\u2010plus measurement in our hospital were included, inclusion criteria being fever above 37\u00b0C, high inflammatory response, and infiltrative pulmonary shadows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients were enrolled. Of these, 15% were QFT positive, 4% were diagnosed with active TB, 76% were QFT negative, 8% had inconclusive results. Sensitivity, specificity, positive predictive value, and negative predictive value were 100%, 87.5%, 28%, and 100%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>QFT\u2010plus may be useful for the diagnosis of active TB in dialysis patients. Further studies in cohorts with larger sample sizes are expected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13939","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T09:29:05Z","timestamp":1665134945000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant diagnosis of tuberculosis in hemodialysis patients using fourth generation interferon \u03b3 releasing assay"],"prefix":"10.1111","volume":"27","author":[{"given":"Miria","family":"Chinen","sequence":"first","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-2644","authenticated-orcid":false,"given":"Daisuke","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Niikura","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minami","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Hinoshita","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Nephrology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Global tuberculosis report 2021.2021."},{"key":"e_1_2_10_3_1","unstructured":"WHO.Latent tuberculosis infection: updated and consolidated guidelines for programmatic management.2018."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029563"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000451"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp030"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00034-13"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01950-19"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2014.11669976"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.35772\/ghm.2020.01036"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.06.017"},{"key":"e_1_2_10_13_1","unstructured":"Tuberculosis in Japan: Annual Report 2021 [cited 2022 Sep 12].https:\/\/jata.or.jp\/english\/dl\/pdf\/TB_in_Japan_2021.pdf."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78374-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00510-2016"}],"container-title":["Therapeutic Apheresis and 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