{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:30:41Z","timestamp":1781008241513,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Platelet abnormalities and secondary thrombocytosis are clinical features of ulcerative colitis (UC) and seem to play a relevant role in pathogenesis. This work analyzed the adsorption characteristics of the adsorber Immunopure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was performed to investigate the module in vitro with blood from healthy donors in a down\u2010scaled recirculation model and in vivo in six patients suffering from UC. Furthermore, adsorber beads were investigated by immunofluorescence analyses. Apheresis was performed over 5\u2009weeks at weekly intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In vitro as well as in vivo, the module showed a strong adsorption of platelets, monocytes, CD14<jats:sup>+<\/jats:sup>CD16<jats:sup>+<\/jats:sup> monocytes, neutrophils, and platelet leukocyte aggregates (PLAs). Five of the six patients benefited from the treatment (83%), and four (67%) went into remission. On average, the CAI was reduced by 6.4 points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Immunopure treatments improved the course of the disease and were well tolerated. The module strongly adsorbs platelets and platelet\u2010aggregates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13942","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T11:43:35Z","timestamp":1666525415000},"page":"452-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adsorptive cytapheresis for ulcerative colitis with focus on removing platelets and platelet\u2010aggregates"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-5027","authenticated-orcid":false,"given":"Matthias","family":"Schneider","sequence":"first","affiliation":[{"name":"Nephrocare Rostock GmbH  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Waitz","sequence":"additional","affiliation":[{"name":"Nephrocare Rostock GmbH  Rostock 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