{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:39:40Z","timestamp":1773023980621,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015731","name":"Bayer Yakuhin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The clinical benefit of vitamin D receptor activators (VDRA) in patients with well\u2010controlled secondary hyperparathyroidism undergoing dialysis remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This post hoc analysis of the LANDMARK study investigates if VDRA use is associated with cardiovascular benefits. Data of 2135 patients undergoing hemodialysis who were at risk for vascular calcification were analyzed using a Cox proportional hazards model with propensity\u2010score matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hazard ratio (HR) for VDRA use was 0.99 (95% confidence interval [CI]: 0.67\u20131.46; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.945) for cardiovascular events and 0.89 (95% CI: 0.62\u20131.28; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.541) for all\u2010cause mortality at baseline. Among patients who always used VDRA, the HR was 1.12 (95% CI: 0.67\u20131.89; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.666) for cardiovascular events and 1.11 (95% CI: 0.67\u20131.85; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.688) for all\u2010cause mortality compared to those who never used VDRA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of VDRA does not reduce the risks of cardiovascular events or all\u2010cause mortality in patients on dialysis with well\u2010controlled secondary hyperparathyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13954","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T06:03:24Z","timestamp":1669788204000},"page":"523-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of vitamin D receptor activators on cardiovascular events in patients on hemodialysis\u2014A post hoc analysis of the 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Metabolism, Department of Internal Medicine Tokai University School of Medicine  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-9201","authenticated-orcid":false,"given":"Tadao","family":"Akizawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hokuto","family":"Morohoshi","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Public Health and Preventive Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Sambe","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Pharmacology Showa University School of Medicine  Tokyo 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