{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:31:53Z","timestamp":1790688713909,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Inadequate dialysis and fluid overload are corrected after starting combined therapy with peritoneal dialysis (PD) and hemodialysis (HD). However, the effects on anemia management has not been elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, multicenter, observational cohort study of 40 PD patients (age, 60\u2009\u00b1\u200910\u2009years; male, 88%; median PD duration, 28\u2009months) starting combined therapy and investigated changes in several clinical parameters, including erythropoiesis\u2010stimulating agent (ESA) resistance index (ERI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ERI decreased significantly during 6\u00a0months after switching to combined therapy (from 11.8 [IQR 8.0\u201320.4] units\/week\/kg\/(g\/dL) to 7.8 [IQR 3.9\u201318.6] units\/week\/kg\/(g\/dL), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047). Body weight, urinary volume, serum creatinine and the dialysate\u2010to\u2010plasma creatinine ratio (D\/P Cr) decreased, whereas hemoglobin and serum albumin increased. In subgroup analysis, the changes in ERI were not affected by cause for starting combined therapy, PD holiday and D\/P Cr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although detailed mechanism was unclear, ESA responsiveness improved after switching from PD alone to combined therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13981","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T13:50:40Z","timestamp":1678456240000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in erythropoiesis\u2010stimulating agent responsiveness after transfer to combined therapy with peritoneal dialysis and hemodialysis for patients on peritoneal dialysis: A prospective multicenter study in Japan"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-8104","authenticated-orcid":false,"given":"Yukio","family":"Maruyama","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Shibagaki Dialysis Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sanaka","sequence":"additional","affiliation":[{"name":"Center of CKD and Lifestyle Related Diseases, Edogawa Hospital  Ichikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology Toho University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Nephrology Toho University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munekazu","family":"Ryuzaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology Tokyo Saiseikai Central Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-0483","authenticated-orcid":false,"given":"Tsutomu","family":"Sakurada","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the EARTH (Evaluation of the Adequacy of Renal replacement THerapy) study 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