{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:14:17Z","timestamp":1773850457215,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lipoprotein apheresis (LA) is a possible adjunct treatment for no\u2010option chronic limb\u2010threatening ischemia (CLTI). This study aimed to assess the impact of a novel LA for no\u2010option CLTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed 19 patients with no\u2010option CLTI treated using the novel LA. The primary outcome was a change in the skin perfusion pressure (SPP) after treatment with LA, and the secondary outcomes were changes in the viscosity\u2010related laboratory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The wound\u2010healing rate was 68.4%. The SPP at 2\u20133\u2009weeks after series of LA were significantly higher both in the dorsal (41 vs. 53\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.037) and plantar (50.0 vs. 61.0\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) sides, compared to those at baseline. The viscosity\u2010related laboratory markers were also significantly improved after the treatment; low\u2010density lipoprotein\u2010cholesterol (57.0 vs. 43.0\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), fibrinogen (333 vs. 258\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and C\u2010reactive protein (0.99 vs. 0.42\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel LA significantly increased the SPP and improved relevant laboratory findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.13991","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T06:15:46Z","timestamp":1681452946000},"page":"960-967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical impact of a novel lipoprotein apheresis treatment on no\u2010option chronic limb\u2010threatening ischemia: Result from the <scp>REDUCTION VISCOSITY<\/scp> study"],"prefix":"10.1111","volume":"27","author":[{"given":"Shunsuke","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center  Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6438","authenticated-orcid":false,"given":"Tatsuya","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center  Urayasu Japan"},{"name":"Division of Vascular Surgery The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-9769","authenticated-orcid":false,"given":"Toshihiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Endocrinology, and Diabetes Tokyo Bay Medical Center  Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Obunai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center  Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center  Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"issue":"39","key":"e_1_2_9_2_1","first-page":"763","article-title":"ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European stroke organization (ESO)the task force for the diagnosis and treatment of peripheral arterial diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)","volume":"2018","author":"Aboyans V","year":"2017","journal-title":"Eur Heart 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