{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:46:05Z","timestamp":1766159165863,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the inflammatory parameters and oxygenation in severe coronavirus disease\u201019 patients who underwent extracorporeal cytokine adsorption (CA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent extracorporeal CA for cytokine storm were included in the study. The changes in oxygenation, laboratory parameters, and mortality rates were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients were included in the study. The hemoglobin, thrombocyte, and C\u2010reactive protein (CRP) decreased, and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>p<\/jats:italic>\u2009=\u20090.04, respectively). Twelve (33.3%) patients received a single session, 24 (66.6%) received 2 or more sessions. CRP and fibrinogen levels decreased, and PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub> ratio increased in the single session group (<jats:italic>p<\/jats:italic>\u2009=\u20090.04; <jats:italic>p<\/jats:italic>\u2009=\u20090.04; <jats:italic>p<\/jats:italic>\u2009=\u20090.01, respectively). In the multi\u2010session group, the hemoglobin, platelet, procalcitonin, and CRP levels decreased, and PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub> ratio increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>p<\/jats:italic>\u2009=\u20090.02; <jats:italic>p<\/jats:italic>\u2009=\u20090.02; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>p<\/jats:italic>\u2009=\u20090.01, respectively). Day 15, 30, and 90 mortality rates were 61.1%, 83.3%, and 88.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CA with hemoperfusion reduced CRP and improved oxygenation; however, mortality rates were high.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14001","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T06:13:39Z","timestamp":1683958419000},"page":"890-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of clinical features and laboratory findings in critical intensive care unit patients with severe coronavirus disease\u201019 who underwent extracorporeal cytokine adsorption"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-2967","authenticated-orcid":false,"given":"Tunzala","family":"Yavuz","sequence":"first","affiliation":[{"name":"Intensive Care Unit Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"},{"name":"Department of Anesthesiology and Reanimation, Intensive Care Unit SBU Tepecik Training and Research Hospital  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-6197","authenticated-orcid":false,"given":"Semiha","family":"Orhan","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-2219","authenticated-orcid":false,"given":"Kazim","family":"Rollas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Intensive Care Unit SBU Tepecik Training and Research Hospital  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-9203","authenticated-orcid":false,"given":"Cansu Koseoglu","family":"Toksoy","sequence":"additional","affiliation":[{"name":"Department of Neurology Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-0964","authenticated-orcid":false,"given":"Elif Dizen","family":"Kazan","sequence":"additional","affiliation":[{"name":"Department of \u0130nternal Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-7098","authenticated-orcid":false,"given":"Erhan","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of \u0130nternal Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-8098","authenticated-orcid":false,"given":"\u0130brahim Guven","family":"Cosgun","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-4668","authenticated-orcid":false,"given":"Filiz","family":"Yavasoglu","sequence":"additional","affiliation":[{"name":"Department of \u0130nternal Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509483"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02020-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2026131"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13144"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00352-9"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Extracorporeal hemoperfusion as a potential therapeutic option for severe COVID\u201019 patients; a narrative review","volume":"8","author":"Safari S","year":"2020","journal-title":"Arch Acad Emerg Med"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508278"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.037"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505565"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499520"},{"key":"e_1_2_6_12_1","unstructured":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Halk Sa\u011fl\u0131\u011f\u0131 Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc.Antisitokin\u2010Antiinflamatuar Tedaviler Koag\u00fclopati Y\u00f6netimi Bilimsel Dan\u0131\u015fma Kurulu \u00c7al\u0131\u015fmas\u0131.2020. Available from:https:\/\/covid19.saglik.gov.tr\/Eklenti\/39296\/0\/covid-19rehberiantisitokin-antiinflamatuartedavilerkoagulopatiyonetimipdf.pdf"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2021.100937"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa387"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01446"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49713"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620937175"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2020.03.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2146"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508125"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-021-00978-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102789"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1847640"},{"issue":"5","key":"e_1_2_6_24_1","first-page":"479","article-title":"Clinical characteristics of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV2) patients in Hospital Tengku Ampuan Afzan","volume":"75","author":"Soh TV","year":"2020","journal-title":"Med J Malaysia"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/jrms.JRMS_1122_20","article-title":"Hemoperfusion in patients with severe COVID\u201019 respiratory failure, lifesaving or not?","volume":"26","author":"Abbasi S","year":"2021","journal-title":"J Res Med Sci"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0530-y"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493523"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14078"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511725"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511391"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2020.1764369"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509107"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12982"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.037"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06211-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30366-0"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50883"},{"key":"e_1_2_6_40_1","article-title":"Efficacy of hemoperfusion in severe and critical cases of COVID\u201019","volume":"52","author":"Darazam IA, Kazempour M, Pourhoseingholi MA, Hatami F, Rabiei, MM, Gharehbagh FJ.","year":"2023","journal-title":"Blood purification"},{"key":"e_1_2_6_41_1","article-title":"Mortality estimation using APACHE and CT scores with stepwise linear regression method in COVID\u201019 intensive care unit: A retrospective study","volume":"88","author":"Ayvat P, Kayhan Omeroglu S","year":"2022","journal-title":"Clinical Imaging"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27182"},{"key":"e_1_2_6_43_1","unstructured":"Nikolas HarbordM JeffreySBernsM AlbertQLamM.https:\/\/www.uptodate.com\/contents\/hemoperfusion?search=hemoperfusion&source=search_result&selectedTitle=1~32&usage_type=default&dis\u20261\/11.2022."},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbab005"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020203557"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2021.01.013"},{"key":"e_1_2_6_47_1","doi-asserted-by":"crossref","unstructured":"Sj\u00f6str\u00f6mA RyszS InstitutetK Sj\u00f6str\u00f6mH H\u00f6ybyeC.Hypernatremia is common in patients with severe COVID\u201019 and indicates a poor prognosis.2020.","DOI":"10.21203\/rs.3.rs-81965\/v1"},{"key":"e_1_2_6_48_1","article-title":"Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study","volume":"368","author":"Chen T","year":"2020","journal-title":"BMJ"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.14001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:41:38Z","timestamp":1693788098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.14001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/1744-9987.14001"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.14001","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"type":"print","value":"1744-9979"},{"type":"electronic","value":"1744-9987"}],"subject":[],"published":{"date-parts":[[2023,5,12]]},"assertion":[{"value":"2022-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}