{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:47:23Z","timestamp":1780984043850,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effects of tenapanor in reducing serum phosphorus in hemodialysis patients with hyperphosphatemia are uncertain and no relevant meta\u2010analysis has been conducted. We performed a meta\u2010analysis of randomized placebo\u2010controlled trials to evaluate the efficacy and safety of tenapanor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All randomized controlled trials of tenapanor were searched up to 1 August 2022. The primary endpoint was the change in serum phosphorus level from baseline with tenapanor and placebo. Data on drug\u2010related adverse events (AEs), gastrointestinal AEs and diarrhea were collected to determine the safety of tenapanor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 533 patients throughout five trials that were eligible. Tenapanor significantly lowered blood phosphorus level by 1.79\u2009mg\/dl in the mean difference than the placebo. Diarrhea, gastrointestinal AEs, and drug\u2010related AEs were more severe than placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis showed that although drug side effects were common, tenapanor significantly reduced serum phosphorus level in hemodialysis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14028","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T23:05:12Z","timestamp":1687647912000},"page":"839-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of tenapanor in hemodialysis patients with hyperphosphatemia: A systematic review and meta\u2010analysis of randomized placebo\u2010controlled trials"],"prefix":"10.1111","volume":"27","author":[{"given":"Houli","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Radiology Cheng du First People's Hospital  Chengdu 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